Results 31 to 40 of about 5,960 (158)

Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension

Frontiers in Molecular Biosciences, 2023
Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has
Michelle N. Sullivan, Pratish Thakore, Vivek Krishnan, Sushma Alphonsa, Wencheng Li, Yumei Feng Earley, Yumei Feng Earley, Scott Earley   +7 more
doaj   +1 more source

TRPA1 is a polyunsaturated fatty acid sensor in mammals.

PLoS ONE, 2012
Fatty acids can act as important signaling molecules regulating diverse physiological processes. Our understanding, however, of fatty acid signaling mechanisms and receptor targets remains incomplete.
Arianne L Motter, Gerard P Ahern
doaj   +1 more source

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo [PDF]

CNS & Neurological Disorders - Drug Targets, 2016
Eleven compounds belonging to the chalcone family were tested for their ability to activate and subsequently desensitize the rat transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 (TRPA1) in a heterologous expression system.
A. Moriello, L. Luongo, F. Guida, M. Christodoulou, D. Perdicchia, S. Maione, D. Passarella, V. Marzo, L. Petrocellis   +8 more
openaire   +5 more sources

Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone

Scientific Reports, 2017
Hydroquinone (HQ) is one of the most frequently used and effective skin-lightening products to treat skin hyperpigmentation disorders, including postinflammatory hyperpigmentation, melasma and solar lentigines. HQ is also widely used in cosmetic products
Yan Tai, Chuan Wang, Zhihua Wang, Yi Liang, Junying Du, Dongwei He, Xiaoyan Fan, Sven-Eric Jordt, Boyi Liu   +8 more
doaj   +1 more source

Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1 [PDF]

PeerJ, 2014
Background and purpose. Arachidonic acid (AA) and its derivatives are important modulators of cellular signalling. The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a cation channel with important functions in mediating ...
William John Redmond, Liuqiong Gu, Maxime Camo, Peter McIntyre, Mark Connor   +4 more
doaj   +2 more sources

ETR and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia

Molecular Pain, 2019
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes transient receptor potential cation channel, subfamily A, member 1 (TRPA1 ...
Xiaoli Zheng, Yan Tai, Dongwei He, Boyu Liu, Chuan Wang, Xiaomei Shao, Sven-Eric Jordt, Boyi Liu   +7 more
doaj   +1 more source

Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system

RSC Advances
The carboxyl-modified ion permeation pathway in TRPA1 channel protein was reconstructed in an artificial system. The transport activity of this artificial channel is tunable via external pH due to the carboxyl groups in the ion permeation pathway.
Pengyang Xin, Wenke Ren, Qiuhui Zhu, Jie Wang, Yonghui Sun, Junbiao Chang, Gongming Zhu   +6 more
openaire   +2 more sources

Unveiling the role of TRPA1 in cardiovascular health and disease: a mini review

Frontiers in Cardiovascular Medicine
The transient receptor potential ankyrin 1 (TRPA1) ion channel has emerged as significant regulators of cardiovascular physiology and pathology. TRPA1 is a non-selective cation channel permeable to calcium ions.
Islam Gellani, Chunqi Qian, Shuangtao Ma
doaj   +1 more source

The Role of TRPA1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice

Pharmaceuticals, 2021
Transient receptor potential ankyrin 1 (TRPA1), a nonselective cation channel, contributes to several (patho)physiological processes. Smell loss is an early sign in several neurodegenerative disorders, such as multiple sclerosis, Parkinson’s and ...
János Konkoly, Viktória Kormos, Balázs Gaszner, Zoltán Sándor, Angéla Kecskés, Ammar Alomari, Alíz Szilágyi, Beatrix Szilágyi, Dóra Zelena, Erika Pintér   +9 more
doaj   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source