Results 21 to 30 of about 5,960 (158)

The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. [PDF]

PLoS ONE, 2013
Transient receptor potential channel ankryn 1 (TRPA1) expressed in the gastrointestinal tract is associated with gastric motility, gastric emptying, and food intake. In this study, we investigated the effects of methyl syringate, a specific and selective
Min Jung Kim, Hee Jin Son, Seo Hyeon Song, Myungji Jung, Yiseul Kim, Mee-Ra Rhyu   +5 more
doaj   +1 more source

Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels [PDF]

Frontiers in Pharmacology, 2019
The sigma 1 receptor (σ1R) and the mu-opioid receptor (MOR) regulate the transient receptor potential (TRP) V1 calcium channel. A series of proteins are involved in the cross-regulation between MORs and calcium channels like the glutamate N-methyl-D-aspartate receptor (NMDAR), including the histidine triad nucleotide-binding protein 1 (HINT1 ...
Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón   +4 more
openaire   +4 more sources

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Lipids in Health and Disease, 2023
Background Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths.
Si Qin, Qian Su, Xiang Li, Muqing Shao, Yindi Zhang, Fadong Yu, Yinxing Ni, Jian Zhong   +7 more
doaj   +1 more source

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

Nature Communications, 2016
The transient receptor potential ankyrin 1 (TRPA1) is a cation channel that is involved in nociceptive pain sensing. Here, the authors show that hydroxylation of a proline in the N terminus of TRPA1 renders it sensitive to reactive oxygen species ...
Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko   +10 more
doaj   +1 more source

TRPA1-dependent and -independent activation by commonly used preservatives

Frontiers in Pharmacology, 2023
Background and purpose: Addition of preservatives ensures microbial stability, especially in multidose containers of parenterally administered pharmaceuticals.
Maximilian L. Mager, Cosmin I. Ciotu, Markus Gold-Binder, Stefan Heber, Michael J. M. Fischer   +4 more
doaj   +1 more source

The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies [PDF]

Allergy, Asthma & Clinical Immunology, 2015
TRPA1 has been proposed to be associated with diverse sensory allergic reactions, including thermal (cold) nociception, hearing and allergic inflammatory conditions. Some naturally occurring compounds are known to activate TRPA1 by forming a Michael addition product with a cysteine residue of TRPA1 through covalent protein modification and, in ...
Mihara, Satoru, Shibamoto, Takayuki
openaire   +4 more sources

Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Cardiovascular Diseases

Frontiers in Physiology, 2020
Cardiovascular disease is one of the chronic conditions with the highest mortality rate in the world. Underlying conditions such as hypertension, metabolic disorders, and habits like smoking are contributors to the manifestation of cardiovascular ...
Song Gao, Keneilwe Kenny Kaudimba, Shanshan Guo, Shuang Zhang, Shuang Zhang, Tiemin Liu, Tiemin Liu, Peijie Chen, Ru Wang   +8 more
doaj   +1 more source

Functionally active TRPA1 ion channel is downregulated in peptidergic neurons of the Edinger-Westphal nucleus upon acute alcohol exposure

Frontiers in Cell and Developmental Biology, 2023
Introduction: The centrally projecting Edinger-Westphal nucleus (EWcp) contributes to the control of alcohol consumption by its urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing peptidergic neurons.
Ammar Al-Omari, Miklós Kecskés, Balázs Gaszner, Tünde Biró-Sütő, Balázs Fazekas, Gergely Berta, Mónika Kuzma, Erika Pintér, Viktória Kormos   +8 more
doaj   +1 more source

Generation of induced pluripotent stem cell line (UKWNLi008) derived from a patient carrying a c.1678C>G variant in the transient receptor potential cation channel subfamily A member (TRPA1) gene potentially associated with small fiber neuropathy

Stem Cell Research, 2023
Using human dermal fibroblasts (hdF) derived from a patient carrying a c.1678C>G variant located in the TRPA1 gene, induced pluripotent stem cells (iPSC) were generated. Cells were reprogrammed via non-modified (NM) RNA-based transfection resulting in three clones. All three clones showed typical embryonic stem cell-like properties including expression
Nicole Michelle Schottmann, Katharina Klug, Eva Klopocki, Nurcan Üçeyler   +3 more
openaire   +3 more sources

Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca2+ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells

Cell Death Discovery, 2023
Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is the third most common cause of malignancy-associated mortality. Distant metastases to the liver and lungs are the main drivers of CRC-dependent death.
Pawan Faris, Agnese Rumolo, Giorgia Pellavio, Matteo Tanzi, Mauro Vismara, Roberto Berra-Romani, Andrea Gerbino, Salvatore Corallo, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia   +11 more
doaj   +1 more source