Results 11 to 20 of about 1,414,547 (185)
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
eLife, 2019 The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek +9 more
doaj +2 more sources
Canadian Journal of Physiology and Pharmacology, 2015 Airway smooth muscle (ASM) contraction controls the airway caliber. Airway narrowing is exaggerated in obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The mechanism by which ASM tone is dysregulated in disease is not clearly understood.
Aruni, Jha +4 more
openaire +3 more sources
The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures
eLife, 2015 While most animals thermotax only to regulate their temperature, female mosquitoes are attracted to human body heat during pursuit of a blood meal.
Román A Corfas, Leslie B Vosshall
doaj +3 more sources
, 2021 Transient receptor potential ankyrin 1 (TRPA1) channel, as a nonselective ligand-gated cation channel robustly in dorsal root ganglion sensory neurons, is implicated in sensing noxious stimuli and nociceptive signaling.
Hang Qi (2317060) +10 more
core +10 more sources
ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN [PDF]
Research Results in Pharmacology, 2015 TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the
Evgeniya Beskhmelnitsyna +5 more
doaj +4 more sources
Ligand determinants of fatty acid activation of the pronociceptive ion channel TRPA1 [PDF]
PeerJ, 2014 Background and purpose. Arachidonic acid (AA) and its derivatives are important modulators of cellular signalling. The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a cation channel with important functions in mediating ...
William John Redmond +4 more
doaj +3 more sources
The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel. [PDF]
Br J Pharmacol, 2017 Background and PurposeThe mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus(L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine.Experimental ApproachSingle‐cell ...
Benemei S +11 more
europepmc +4 more sources
Pyrazine-fused triterpenoids block the TRPA1 ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo [PDF]
, 2019 TRPA1 is a nonselective cation channel, most famously expressed in nonmyelinated nociceptors. In addition to being an important chemical and mechanical pain sensor, TRPA1 has more recently appeared to have a role also in inflammation.
Moreira, V.M. +34 more
core +4 more sources
The role of TRPA1 channels in thermosensation
Cell Insight, 2022 Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in ...
Hao Zhang +6 more
doaj +1 more source
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
doaj +1 more source