Results 11 to 20 of about 5,960 (158)
Function and therapeutic potential of transient receptor potential ankyrin 1 in fibrosis
Frontiers in Pharmacology, 2022 The transient receptor potential (TRP) protein superfamily is a special group of cation channels expressed in different cell types and signaling pathways.
Yicheng Wei +10 more
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The role of TRPA1 channels in thermosensation
Cell Insight, 2022 Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in ...
Hao Zhang +6 more
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Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
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A thermogenetics protocol for detecting gap junction channels in Drosophila egg chambers
STAR Protocols, 2021 Summary: In this protocol, we took a “thermogenetics” approach to detect functional gap junction channels between cells in Drosophila egg chambers. We expressed the thermosensitive cation channel TrpA1-A in the germline using Gal4, and a fluorescent [Ca2+
Guangxia Miao, Denise Montell
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GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion [PDF]
Molecular Endocrinology, 2016 GPR119 is a G protein-coupled receptor expressed on intestinal L cells that synthesize and secrete the blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1). GPR119 agonists stimulate the release of GLP-1 from L cells, and for this reason there is interest in their potential use as a new treatment for type 2 diabetes mellitus. AS1269574 is one
Oleg G, Chepurny +3 more
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Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1
Biochemistry and Biophysics Reports, 2021 Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective cation channel expressed on nociceptive sensory nerves whose activation elicits nocifensive responses (e.g. pain).
Thomas A. Parks +2 more
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Health Science Reports, 2022 AbstractBackground and AimsThe transient receptor potential cationic channel ankyrin 1 (TRPA1), a channel protein permeable to most divalent cations, has been suggested to play a role in mechano‐afferent/efferent signaling (including the release of neurotransmitters) in the human urinary tract (bladder, prostate, and urethra).
Harrina E. Rahardjo +3 more
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ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN [PDF]
Research Results in Pharmacology, 2015 TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the
Evgeniya Beskhmelnitsyna +5 more
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Journal of Inflammation, 2018 Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger.
Songjiang Yin +7 more
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Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
eLife, 2019 The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek +9 more
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