Results 41 to 50 of about 5,960 (158)
Upregulation of TRPM3 in nociceptors innervating inflamed tissue
eLife, 2020 Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown.
Marie Mulier +7 more
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TRPA1 expression and its functional activation in rodent cortex [PDF]
Open Biology, 2017 TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Kheradpezhouh +3 more
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Can trigeminal sensations impact saltiness perception? A mini‐review
Journal of the Science of Food and Agriculture, EarlyView.Abstract Many food companies have begun to reduce the salt content in their products due to health concerns; however, this reduction in salt content can affect the food's sensory appeal and flavour complexity. Flavour is defined as a combination of odour (i.e., smell), taste (i.e., gustation) and trigeminal sensations (i.e., chemesthesis).
Emily Dolan +2 more
wiley +1 more source
Pore dilation occurs in TRPA1 but not in TRPM8 channels
Molecular Pain, 2009 Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to their selective permeation of small cations (e.g., Ca2+,
Faltynek Connie R +6 more
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Environmental Toxicology, EarlyView.ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye +5 more
wiley +1 more source
Frontiers in Physiology, 2016 The transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is conserved between many arthropods, and in some has been shown to function as a chemosensor for noxious compounds.
Guangda Peng +5 more
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Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)
Integrative Zoology, EarlyView.Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells
Journal of Pain Research, 2020 Jie Liu,1,* Kehua Que,1,* Yangqiu Liu,1 Chengcheng Zang,1 Jing Wen1,2 1Department of Endodontics, College of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Lotus Dental Clinic, Guangzhou, Guangdong Province, People ...
Liu J, Que K, Liu Y, Zang C, Wen J
doaj
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source