Results 1 to 10 of about 145,724 (263)

Drugs for treating myocardial fibrosis

Frontiers in Pharmacology, 2023
Myocardial fibrosis, which is a common pathological manifestation of many cardiovascular diseases, is characterized by excessive proliferation, collagen deposition and abnormal distribution of extracellular matrix fibroblasts.
Zhanhong Ren, Zixuan Zhang, Zixuan Zhang, Li Ling, Xiufen Liu, Xin Wang   +5 more
doaj   +3 more sources

RNA 5-Methylcytosine Modification in Myocardial Fibrosis [PDF]

Reviews in Cardiovascular Medicine
Myocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj   +2 more sources

Blood Immune Cell Alterations in Patients with Hypertensive Left Ventricular Hypertrophy and Heart Failure with Preserved Ejection Fraction

Journal of Cardiovascular Development and Disease, 2023
(1) Background: Chronic inflammation and fibrosis are key players in cardiac remodeling associated with left ventricular hypertrophy (LVH) and heart failure with a preserved ejection fraction (HFpEF). Monocytes and T-helpers (Th) are involved in both pro-
Artem Ovchinnikov, Anastasiya Filatova, Alexandra Potekhina, Tatiana Arefieva, Anna Gvozdeva, Fail Ageev, Evgeny Belyavskiy   +6 more
doaj   +1 more source

MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension

Cardiovascular Therapeutics, 2022
Background. Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. But cardiac fibrosis mechanism remains unclear.
Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian   +8 more
doaj   +1 more source

SARC Gene Mutation Is Associated With Myocardial Fibrosis Measured by Histopathology and Cardiac Magnetic Resonance in Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Sarcomere gene mutation and myocardial fibrosis are both associated with poorer clinical outcomes in patients with hypertrophic cardiomyopathy (HCM).
Manyun Huang, Jian Zhang, Changpeng Song, Shuiyun Wang, Zhou Zhou, Hongyue Wang, Shihua Zhao, Kunlun Yin, Li Li, Shujuan Yang, Xinxin Zheng, Jie Lu, Xiaohong Huang   +12 more
doaj   +1 more source

Methyl Ferulic Acid Attenuates Human Cardiac Fibroblasts Differentiation and Myocardial Fibrosis by Suppressing pRB-E2F1/CCNE2 and RhoA/ROCK2 Pathway

Frontiers in Pharmacology, 2021
Background: Myocardial fibrosis is a key pathological process after myocardial infarction, which leads to poor outcomes in patients at the end stage. Effective treatments for improving prognosis of myocardial fibrosis are needed to be further developed ...
Rongheng Liao, Zhen Qi, Ri Tang, Renrong Wang, Yongyi Wang   +4 more
doaj   +1 more source

Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis

Chinese Medicine, 2022
Background Myocardial fibrosis changes the structure of myocardium, leads to cardiac dysfunction and induces arrhythmia and cardiac ischemia, threatening patients’ lives.
Wenchuan Qi, Xiang Li, Yanrong Ren, Xueying Liu, Hongjuan Fu, Xiao Wang, Xiao Li, Jian Xiong, Qianhua Zheng, Dingjun Cai, Fanrong Liang   +10 more
doaj   +1 more source

Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload

International Journal of Hypertension, 2020
Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts.
Yuejia Ding, Yuan Wang, Qiujin Jia, Xiaoling Wang, Yanmin Lu, Ao Zhang, Shichao Lv, Junping Zhang   +7 more
doaj   +1 more source

Fragmented QRS complex as a marker of myocardial fibrosis in patients with coronary artery disease [PDF]

Наука и инновации в медицине, 2022
Aim– to analyze the relationship between fQRS and myocardial fibrosis in CAD patients using SPECT. Material and methods.Retrospectively, we have analyzed the anamnesis and examinations of 116 patients with suspected coronary heart disease.
Mariya S. Gordeeva, Elena V. Parmon, Veronika A. Karlina, Darya V. Ryzhkova   +3 more
doaj   +1 more source

Elucidating the role of circNFIB in myocardial fibrosis alleviation by endogenous sulfur dioxide

BMC Cardiovascular Disorders, 2022
Background To investigate the role of circNFIB in the alleviation of myocardial fibrosis by endogenous sulfur dioxide (SO2). Methods We stimulated cultured neonatal rat cardiac fibroblasts with transforming growth factor-β1 (TGF-β1) and developed an in ...
Jia Liu, Ranran Zhang, Dahai Wang, Yi Lin, Cui Bai, Nana Nie, Shan Gao, Qiuye Zhang, Hong Chang, Chongmin Ren   +9 more
doaj   +1 more source