Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1. [PDF]
, 2016 TGF-β-induced endothelial-to-mesenchymal transition (EndoMT) is a newly recognized source of profibrotic activated myofibroblasts and has been suggested to play a role in the pathogenesis of various fibrotic processes.
Jimenez, Sergio A. +3 more
core +15 more sources
GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV pathogenesis. [PDF]
PLoS ONE, 2012 Elevated levels of the immunoregulatory cytokine TGF-β1 in cancer and HIV infection have been linked to the suppression of protective immune responses. The transcriptional regulation of TGF-β1 is complex and still not completely understood.
Robert L Furler +1 more
doaj +1 more source
Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1. [PDF]
PLoS ONE, 2013 Transforming growth factor β1 (TGF-β1) is the pivotal pro-fibrogenic cytokine in hepatic fibrosis. Reducing the over-produced expression of TGF-β1 or blocking its signaling pathways is considered to be a promising therapeutic strategy for hepatic ...
Xiaobao Fan +6 more
doaj +1 more source
Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease
Frontiers in Immunology, 2022 Chronic liver disease (CLD) is an extremely common clinical condition accompanied by sustained inflammatory response leading to tissue damage. Transforming growth factor-β1 (TGF-β1) is known as a master immune regulator in CLDs, but the association ...
Xuanyan Cai +19 more
doaj +1 more source
Frontiers in Veterinary Science, 2021 Cancer cells can evade host immune systems via multiple mechanisms. Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive cytokine that induces regulatory T cell (Tregs) differentiation and is involved in immune evasion mechanisms in cancer.
Hiroto Takeuchi +16 more
doaj +1 more source
TGF-β1 exerts opposing effects on grass carp leukocytes: implication in teleost immunity, receptor signaling and potential self-regulatory mechanisms. [PDF]
PLoS ONE, 2012 In fish immunity, the regulatory role of transforming growth factor-β1 (TGF-β1) has not been fully characterized. Here we examined the immunoregulatory effects of TGF-β1 in grass carp peripheral blood leukocytes (PBL) and head kidney leukocytes (HKL). It
Mu Yang +5 more
doaj +1 more source
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy. [PDF]
PLoS ONE, 2013 To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral ...
Jigna Narola +3 more
doaj +1 more source
The relationship between TGF-β1 and cognitive function in the brain
Brain Research Bulletin, 2023 Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation.
Chen Su, Jie Miao, Junhong Guo
doaj +1 more source
Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts. [PDF]
PLoS ONE, 2014 BACKGROUND: We have previously reported that repeated treatment of human periodontal ligament cells and murine pre-osteoblast MC3T3-E1 cells with transforming growth factor-beta 1 (TGF-β1) inhibited their osteoblastic differentiation because of decreased
Eiichi Suzuki +6 more
doaj +1 more source
Open Life Sciences, 2021 Transforming growth factor (TGF)-β1 and mesenchymal stromal cells (MSCs) are two effective immunosuppressive agents for organ transplantation technology.
Li Ruixue +6 more
doaj +1 more source