GLI2 regulates TGF-β1 in human CD4+ T cells: implications in cancer and HIV pathogenesis. [PDF]
PLoS ONE, 2012 Elevated levels of the immunoregulatory cytokine TGF-β1 in cancer and HIV infection have been linked to the suppression of protective immune responses. The transcriptional regulation of TGF-β1 is complex and still not completely understood.
Robert L Furler +1 more
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Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-β1. [PDF]
PLoS ONE, 2013 Transforming growth factor β1 (TGF-β1) is the pivotal pro-fibrogenic cytokine in hepatic fibrosis. Reducing the over-produced expression of TGF-β1 or blocking its signaling pathways is considered to be a promising therapeutic strategy for hepatic ...
Xiaobao Fan +6 more
doaj +1 more source
Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease
Frontiers in Immunology, 2022 Chronic liver disease (CLD) is an extremely common clinical condition accompanied by sustained inflammatory response leading to tissue damage. Transforming growth factor-β1 (TGF-β1) is known as a master immune regulator in CLDs, but the association ...
Xuanyan Cai +19 more
doaj +1 more source
Frontiers in Veterinary Science, 2021 Cancer cells can evade host immune systems via multiple mechanisms. Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive cytokine that induces regulatory T cell (Tregs) differentiation and is involved in immune evasion mechanisms in cancer.
Hiroto Takeuchi +16 more
doaj +1 more source
TGF-β1 exerts opposing effects on grass carp leukocytes: implication in teleost immunity, receptor signaling and potential self-regulatory mechanisms. [PDF]
PLoS ONE, 2012 In fish immunity, the regulatory role of transforming growth factor-β1 (TGF-β1) has not been fully characterized. Here we examined the immunoregulatory effects of TGF-β1 in grass carp peripheral blood leukocytes (PBL) and head kidney leukocytes (HKL). It
Mu Yang +5 more
doaj +1 more source
THU0004 MICRORNA-223 NEGATIVELY REGULATE GOUTY INFLAMMATION BY TARGETING THE NLRP3 INFLAMMASOME WITHOUT INFLUENCING IL-37 AND TGF-î'1 [PDF]
Annals of the Rheumatic Diseases, 2019 Background MicroRNA-223 (miR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders[1]. To date, no relevant studies have reported the expression levels of miR-223 in gout patients or assessed whether miR-223 participates in negatively regulating gouty inflammation via ...
Yu-Feng Qing +5 more
openaire +1 more source
The relationship between TGF-β1 and cognitive function in the brain
Brain Research Bulletin, 2023 Transforming growth factor-β1 (TGF-β1), a multifunctional cytokine, plays a pivotal role in synaptic formation, plasticity, and neurovascular unit regulation.
Chen Su, Jie Miao, Junhong Guo
doaj +1 more source
Conditional expression of TGF-β1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy. [PDF]
PLoS ONE, 2013 To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral ...
Jigna Narola +3 more
doaj +1 more source
Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts. [PDF]
PLoS ONE, 2014 BACKGROUND: We have previously reported that repeated treatment of human periodontal ligament cells and murine pre-osteoblast MC3T3-E1 cells with transforming growth factor-beta 1 (TGF-β1) inhibited their osteoblastic differentiation because of decreased
Eiichi Suzuki +6 more
doaj +1 more source
The Egyptian Heart Journal, 2021 Background Coronary artery ectasia (CAE) is described as the enlargement of a coronary artery segment by 1.5 times or more, which is generally associated with the atherosclerotic process. Atherosclerotic changes lead to arterial remodeling result in CAE.
Özgür Selim Ser +10 more
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