Results 31 to 40 of about 113,485 (253)

Additional file 1: of Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

, 2016
Presents the supplementary methods. (DOC 54 kb)
Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Zhang, Lei, Zhang, Chao, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Liang, Wei   +9 more
openaire   +1 more source

TGF-β1-Induced Epithelial–Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells [PDF]

Frontiers in Oncology, 2015
Breast cancer progression toward metastatic disease is linked to re-activation of epithelial-mesenchymal transition (EMT), a latent developmental process. Breast cancer cells undergoing EMT lose epithelial characteristics and gain the capacity to invade the surrounding tissue and migrate away from the primary tumor.
Johansson J, Tabor V, Wikell A, Jalkanen S, Fuxe J   +4 more
openaire   +6 more sources

Preparation and functional identification of anti-human transforming growth factor β1 nanobodies [PDF]

Jichu yixue yu linchuang, 2020
Objective To prepare alpaca-derived anti-human TGF-β1 nanobodies with high specificity and high affinity. Methods The eukaryotic expression plasmid cFUGW-TGF-β1 was constructed and transiently transfected into HEK-293T cells to obtain recombinant TGF-β1 ...
WANG Yue, LI Zheng, CHEN Hui, ZHANG Jian-min, HE Wei
doaj  

The mRNA-binding protein DDX3 mediates TGF-β1 upregulation of translation and promotes pulmonary fibrosis

JCI Insight, 2023
Pulmonary fibrosis is potentiated by a positive feedback loop involving the extracellular sialidase enzyme neuraminidase 3 (NEU3) causing release of active TGF-β1 and TGF-β1 upregulating NEU3 by increasing translation without affecting mRNA levels.
Wensheng Chen, Darrell Pilling, Richard H. Gomer   +2 more
doaj   +1 more source

CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung [PDF]

Frontiers in Pharmacology, 2014
Pulmonary fibrosis is a difficult to treat, often fatal disease whose pathogenesis involves dysregulated TGF-β1 signaling. CD4+CD25+FoxP3+ Regulatory T cells ("Tregs") exert important effects on host tolerance and arise from naïve CD4+ lymphocytes in response to TGF-β1.
Peng, Xueyan, Moore, Meagan W., Peng, Hong, Sun, Huanxing, Gan, Ye, Homer, Robert J., Herzog, Erica L.   +6 more
openaire   +3 more sources

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity.
Xiaofang Wang, Fang Dong, Sen Zhang, Wanzhu Yang, Wenying Yu, Zhao Wang, Shanshan Zhang, Jinhong Wang, Shihui Ma, Peng Wu, Yun Gao, Ji Dong, Fuchou Tang, Tao Cheng, Hideo Ema   +14 more
doaj   +1 more source

Additional file 4: Table S3. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
List of primer sequences for genes probed on quantitative real time PCR. (PDF 26 kb)
Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan, White, Jacob, Yu, Hanry, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Injectable agents for the induction of Peyronie’s disease in model rats: a comparative study

Asian Journal of Andrology
Peyronie’s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages.
Guang-Jun Du, Si-Yan Xing, Ning Wu, Tong Wang, Yue-Hui Jiang, Tao Song, Bai-Bing Yang, Yu-Tian Dai   +7 more
doaj   +1 more source

A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells. [PDF]

PLoS ONE, 2012
Transforming growth factor β (TGF-β) induces the process of epithelial-mesenchymal transition (EMT) through the Smad and JNK signaling. However, it is unclear how these pathways interact in the TGF-β1-induced EMT in rat peritoneal mesothelial cells ...
Qinghua Liu, Yu Zhang, Haiping Mao, Wei Chen, Ning Luo, Qin Zhou, Wenfang Chen, Xueqing Yu   +7 more
doaj   +1 more source