Results 11 to 20 of about 239,501 (262)

The Epigenetically-Regulated microRNA-378a Targets TGF-β2 in TGF-β1-Treated Hepatic Stellate Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: In liver fibrosis, the activation of hepatic stellate cells (HSCs) is considered as a pivotal event. It is well known that transforming growth factor-β1 (TGF-β1) is the main stimuli factor responsible for HSC activation.
Fujun Yu, Jianhuan Yang, Kate Huang, Xiaodong Pan, BiCheng Chen, Peihong Dong, Jianjian Zheng   +6 more
doaj   +2 more sources

Noggin inhibits TGF-β1 OR TGF-β3 induced chondrogenesis of mesenchymal stromal cells [PDF]

European Cells & Materials
Noggin (NOG) is an antagonist of bone morphogenetic proteins (BMPs), which regulates development and homeostasis of bone and cartilage. NOG has also been discovered to be an antagonist of transforming growth factor-β1 (TGF-β1). However, the effect of NOG
L Wen, AR Armiento, AG Guex, S Grad, L Creemers, MJ Stoddart   +5 more
doaj   +3 more sources

TGF-β1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells

, 2023
Aging-related salivary gland degeneration usually causes poor oral health. Periductal fibrosis frequently occurs in the submandibular gland of the elderly.
Xiangqin Chen (16793087), Zheng Li (26302), Wanghua Song, Zheng Li, Zhuo Chen, Yao Hou, Hanjie Yu (605875), Xiangqin Chen, Xiaojuan Bao, Wanghua Song (16793090), Zhuo Chen (135585), Shisheng Sun (125326), Bojing Zhu, Bojing Zhu (6618569), Yao Hou (4035860), Xiaojuan Bao (12483715), Hanjie Yu, Shisheng Sun   +17 more
core   +1 more source

TGF-β1 and M4 TCM alter gene expression.

, 2023
(A) RT-qPCR for PAI1 and KLF10 expression in dHL-60 cells treated with 2 ng/ml TGF-β1 for 30 min. (B) RT-qPCR for SMAD7 and KLF10 expression in dHL-60 cells treated with 2 ng/ml TGF-β1 for 30 min that were sent for RNA-seq.
Carole A. Parent (10582907), Craig N. Johnson (16954685), Lauren E. Hein (10582904), Gaurie Gunasekaran (16954682), Shuvasree SenGupta (7343309)   +4 more
core   +1 more source

Nanoparticle-mediated local delivery of an antisense TGF-β1 construct inhibits intimal hyperplasia in autogenous vein grafts in rats. [PDF]

PLoS ONE, 2012
Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening.In the present study ...
Da-Xin Sun, Zhen Liu, Xiao-Dong Tan, Dong-Xu Cui, Bao-Sheng Wang, Xian-Wei Dai   +5 more
doaj   +1 more source

A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK

Biology, 2020
Transforming growth factor-β1 (TGF-β1) is highly expressed in the tumor microenvironment and known to play a multifunctional role in cancer progression.
Ji-Hoon Jeong, Hyunhee Kim, Seung-Ho Park, Hayeon Park, Minseok Jeong, Sungmin Kwak, Gi-Jun Sung, Ji-Hye Song, Younghwa Na, Kyung-Chul Choi   +9 more
doaj   +1 more source

TGF-β1 pathways remain activated in SIV+ animals despite viral suppression with ART.

, 2023
(A) Representative images of IHC performed on frontal cortex tissue of SIV+ animals (acute [n = 4], chronic [n = 8] or virally suppressed [VS; n = 11]) or uninfected controls (n = 4) for Iba1 (myeloid cells), pSMAD3, TGF-β1 and DAPI.
Kathleen Busman-Sahay (276439), Skyler Younger (14857065), Michael Roche (81866), Melissa J. Churchill (9218257), Sarah J. Byrnes (14857062), Thomas A. Angelovich (9218251), Michael Nekorchuk (186957), Jacob D. Estes (7517873), Steven E. Bosinger (8777792), Claire Deleage (322572), Margaret Terry (14857074), Mirko Paiardini (243070), Trisha A. Jenkins (3934424), Catherine R. Cochrane (14857077), Rachel Dannay (14857071), Sol Taylor-Brill (14857068), Stephen Bondoc (10777102), Bruce J. Brew (11411066)   +17 more
core   +1 more source

TGF-β1-overexpressing mesenchymal stem cells reciprocally regulate Th17/Treg cells by regulating the expression of IFN-γ

Open Life Sciences, 2021
Transforming growth factor (TGF)-β1 and mesenchymal stromal cells (MSCs) are two effective immunosuppressive agents for organ transplantation technology.
Li Ruixue, Wang Renyong, Zhong Shijie, Asghar Farhan, Li Tiehan, Zhu Lei, Zhu Hong   +6 more
doaj   +1 more source

Gene Transfection and Expression of Transforming Growth Factor-β1 in Nonobese Diabetic Mouse Islets Protects β-Cells in Syngeneic Islet Grafts from Autoimmune Destruction

Cell Transplantation, 2002
Nonobese diabetic (NOD) mice develop diabetes and destroy syngeneic islet grafts through an autoimmune response. Because transforming growth factor (TGF)-β1 downregulates immune responses, we tested whether overexpression of TGF-β1 by gene transfection ...
Wilma L. Suarez-Pinzon, Yvonne Marcoux, Aziz Ghahary, Alex Rabinovitch M.D.   +3 more
doaj   +1 more source

TGF-β1 induces canonical SMAD3 phosphorylation in neutrophils.

, 2023
(A) Immunoblots for pSMAD3C and GAPDH in dHL-60 cells in response to varying doses of TGF-β1. (B) Quantification of (A). (C) Immunoblots of pSMAD3C and GAPDH in dHL-60 cells in response to 2 ng/ml TGF-β1 after pretreatment with varying doses of SB431542.
Carole A. Parent (10582907), Craig N. Johnson (16954685), Lauren E. Hein (10582904), Gaurie Gunasekaran (16954682), Shuvasree SenGupta (7343309)   +4 more
core   +1 more source