Results 21 to 30 of about 166,365 (294)

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

IL-10 and TGF-β1 evaluation in 3D human adipose-derived mesenchymal stem cells culture and hypoxic condition

Bioscience Journal, 2018
Mesenchymal stem cells (MSC) are multipotent cells derived from layer mesoderm and that have potential for self-renewal and cellular differentiation. These cells can be extracted from various tissues, being the main sources the bone marrow (BM) and adipose tissue (AT).
Vivian Alonso Goulart, Bárbara Cândido de Oliveira, Yasmin Twanne de Cássia Silva, Jéssica Regina Costa Silva, Cristiane Angélico Duarte, Isabela Lemos de Lima   +5 more
openaire   +4 more sources

miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM [PDF]

Molecular Therapy - Nucleic Acids, 2020
Dysregulated expression of microRNAs (miRNAs or miRs) has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). However, their underlying role in the complication of detrusor fibrosis remains poorly understood. Therefore, this study aimed to examine the potential functional relevance of miR-363 in detrusor fibrosis of rats with ...
Xue-Feng Li, Shu-Hua Zhang, Gui-Feng Liu, Shao-Nan Yu   +3 more
openaire   +5 more sources

TGF-β1 on induced osteogenic differentiation of human dermal fibroblast [PDF]

, 2014
PURPOSE:To evaluate the role of transforming growth factor beta 1 (TGF-β1) on the induced osteogenic differentiation of human dermal fibroblasts.METHODS:We performed four groups with cultured dermal fibroblasts according to the culture medium: CONTROL ...
Aloise, Antonio Carlos, Duailibi, Silvio Eduardo, Ferreira, Lydia Masako, Gragnani, Alfredo, Pereira, Max Domingues   +4 more
core   +3 more sources

Hubungan Kadar TGF-β1 dan IFN-ɣ dengan Indeks Kronisitas Nefritis Lupus

Jurnal Kedokteran Brawijaya, 2013
Meskipun perbaikan penatalaksanaan terapi telah dilakukan dalam dua dekade terakhir , tetapi prognosis nefritis lupus tetap  tidak  memuaskan.  Oleh  karena  itu  diperlukan  suatu  biomarker  yang  dapat  menggambarkan  aktivitas  penyakit. Penelitian ini  dilakukan untuk untuk melihat peran TGF-β1 urin dan IFN-ɣ  urin sebagai ...
Indah Jayani, Kusworini Handono, Agustina Tri E   +2 more
openaire   +2 more sources

Gene Transfection and Expression of Transforming Growth Factor-β1 in Nonobese Diabetic Mouse Islets Protects β-Cells in Syngeneic Islet Grafts from Autoimmune Destruction

Cell Transplantation, 2002
Nonobese diabetic (NOD) mice develop diabetes and destroy syngeneic islet grafts through an autoimmune response. Because transforming growth factor (TGF)-β1 downregulates immune responses, we tested whether overexpression of TGF-β1 by gene transfection ...
Wilma L. Suarez-Pinzon, Yvonne Marcoux, Aziz Ghahary, Alex Rabinovitch M.D.   +3 more
doaj   +1 more source

Biomarkers and overall survival in patients with advanced hepatocellular carcinoma treated with TGF-βRI inhibitor galunisertib. [PDF]

, 2020
BackgroundTransforming growth factor beta (TGF-β) signalling is involved in the development of hepatocellular carcinoma (HCC). We followed changes in biomarkers during treatment of patients with HCC with the TGF-βRI/ALK5 inhibitor galunisertib ...
Benhadji, Karim A, Cleverly, Ann, Estrem, Shawn T, Faivre, Sandrine, Gane, Ed, Giannelli, Gianluigi, Kelley, Robin K, Lahn, Michael M, Man, Michael, Paradis, Valerie, Raymond, Eric, Santoro, Armando, Smith, Claire, Wang, Shuaicheng   +13 more
core   +2 more sources

Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats

International Journal of Endocrinology, 2019
Objective. To investigate the role of microRNA-130b in 1,25(OH)2D3 mediated improvement of renal fibrosis via transforming growth factor-beta 1 in a rat model of diabetic nephropathy (DN). Methods.
Yuetong Liu, Ye Yang, Qin Wang, Apaer Kahaer, Jiyun Zhang, Jing Liao, Mairemugu Abudureyimu, Reyila Yahefu, Jing Qi, Lei Zhao, Jun Zhu   +10 more
doaj   +1 more source

High glucose-induced Matrilin-2 expression in mouse mesangial cells was mediated by transforming growth factor beta 1 (TGF-β1) [PDF]

, 2016
This study aimed at evaluating the effect of high glucose on the expression of extracellular matrix (ECM) protein Matrilin-2 and the mechanism underlying this effect by using a mouse mesangial cell line.
Du, Yanshneg, Huang, Hong, Luo, Junming, Yi, Xin, Zhang, Menglan, Zhang, Shukun, Zhou, Shiying   +6 more
core   +1 more source

Transforming growth factor-β1 and -β2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro. [PDF]

PLoS ONE, 2013
Transforming growth factor-β1 (TGF-β1) and -β2 are correlated with poorer prognosis in gastric cancer (GC), which act in both tumor and immune cells. However, their expressions in precancer and tumor-cell interactions with peripheral blood mononuclear ...
Gui-Fen Ma, Qing Miao, Xiao-Qing Zeng, Tian-Cheng Luo, Li-Li Ma, Yi-Mei Liu, Jing-Jing Lian, Hong Gao, Shi-Yao Chen   +8 more
doaj   +1 more source