Results 51 to 60 of about 239,501 (262)
HIF‐1α modulates pancreatic cancer ECM proteins via the TGF‐β1/Smad signaling pathway introduction
Frontiers in OncologyIntroductionPancreatic cancer is characterized by its aggressive nature and poor prognosis, ranking among the most lethal malignancies. The tumor microenvironment, particularly the extracellular matrix (ECM), plays a crucial role in cancer progression ...
Houle Guo +3 more
doaj +1 more source
Mediators of Inflammation, 1995 We investigated the effect of transforming factor factor-β1 (TGF-β1) on thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) production in in vitro silica dust-exposed rat alveolar macrophages (AM).
Urszula Orlinska, Douglas C. Kuhn
doaj +1 more source
Biomedical Journal, 2016 Background: By transdifferentiation, proximal tubular cells (PTC) have been considered as a source of interstitial myofibroblasts. We examined the combined effect of transforming growth factor-beta-1 (TGF-β1) stimulation and contact with type I collagen ...
Chieh-Li Yen +11 more
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Transforming Growth Factor-Beta1 in Diabetic Kidney Disease
Frontiers in Cell and Developmental Biology, 2020 Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Renin-angiotensin-aldosterone system (RAAS) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown efficacy in reducing the risk of ESRD.
Lijun Zhao, Yutong Zou, Fang Liu
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TGF-β1, IL-6 and IL-17 mRNA expression of NRK-52E after co-stimulation by TGF-β1 and IL-6.
, 2016 Relative TGF-β1 (A), IL-6 (B) and IL-17 (C) mRNA expression of non-stimulated NRK-52E (nc) and at different time points after co-stimulation by 5 ng/ml TGF- β1 and 10 ng/ml IL-6.
Stephanie Krämer (3165525) +4 more
core +1 more source
Possible Consequences for TGF-β1 Signaling [PDF]
, 2017 Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity in ...
Samsonov, Sergey +6 more
core +1 more source
Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Transforming growth factor-β1 (TGF-β1) plays important roles in chronic liver diseases, including metabolic dysfunction–associated steatotic liver disease (MASLD). MASLD involves various biological processes including dysfunctional
Sai Wang +17 more
doaj +1 more source
TGF-β1, IL-6 and IL-17 mRNA expression of NRK-52E after glucose, IL-6, TGF-β1 or IL-17 stimulation.
, 2016 TGF-β1, IL-6 and IL-17 mRNA expression in NRK-52E cells 15 min after stimulation by 25 mM glucose, 10 ng/ml IL-6, 5 ng/ml TGF-β1 or 25 ng/ml IL-17. Analysis utilized real-time PCR and was normalized to β-actin as housekeeping gene. (# p
Stephanie Krämer (3165525) +4 more
core +1 more source
Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo +11 more
wiley +1 more source