Results 51 to 60 of about 166,365 (294)

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity.
Xiaofang Wang, Fang Dong, Sen Zhang, Wanzhu Yang, Wenying Yu, Zhao Wang, Shanshan Zhang, Jinhong Wang, Shihui Ma, Peng Wu, Yun Gao, Ji Dong, Fuchou Tang, Tao Cheng, Hideo Ema   +14 more
doaj   +1 more source

A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells. [PDF]

PLoS ONE, 2012
Transforming growth factor β (TGF-β) induces the process of epithelial-mesenchymal transition (EMT) through the Smad and JNK signaling. However, it is unclear how these pathways interact in the TGF-β1-induced EMT in rat peritoneal mesothelial cells ...
Qinghua Liu, Yu Zhang, Haiping Mao, Wei Chen, Ning Luo, Qin Zhou, Wenfang Chen, Xueqing Yu   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Additional file 1: of Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

, 2016
Presents the supplementary methods. (DOC 54 kb)
Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Zhang, Lei, Zhang, Chao, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Liang, Wei   +9 more
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Stimulation of transforming growth factor-beta-1 and contact with type I collagen cooperatively facilitate irreversible transdifferentiation in proximal tubular cells

Biomedical Journal, 2016
Background: By transdifferentiation, proximal tubular cells (PTC) have been considered as a source of interstitial myofibroblasts. We examined the combined effect of transforming growth factor-beta-1 (TGF-β1) stimulation and contact with type I collagen ...
Chieh-Li Yen, Yi-Jung Li, Hsin-Hsu Wu, Cheng-Hao Weng, Cheng-Chia Lee, Yung-Chang Chen, Ming-Yang Chang, Tzung-Hai Yen, Hsiang-Hao Hsu, Cheng-Chieh Hung, Chih-Wei Yang, Ya-Chung Tian   +11 more
doaj   +1 more source

Transforming Growth Factor-Beta1 in Diabetic Kidney Disease

Frontiers in Cell and Developmental Biology, 2020
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Renin-angiotensin-aldosterone system (RAAS) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown efficacy in reducing the risk of ESRD.
Lijun Zhao, Yutong Zou, Fang Liu
doaj   +1 more source

A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways [PDF]

, 2017
Renal fibrosis is closely related to chronic inflammation and is under the control of epigenetic regulations. Because the signaling of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) play key roles in progression of renal ...
Abe, Takaaki, Akiyama, Yasutoshi, Akiyama, Yukako, Hayashi, Ken-ichiro, Ho, Hsin-Jung, Ito, Sadayoshi, Kikuchi, Koichi, Kobayashi, Takayasu, Masaki, Takao, Masamune, Atsushi, Matsuhashi, Tetsuro, Matsuo, Akihiro, Mishima, Eikan, Mukawa, Chikahisa, Nanto, Fumika, Oba, Yuki, Obara, Ten, Oikawa, Yoshitsugu, Saigusa, Daisuke, Sasaki, Kensuke, Shima, Hisato, Suzuki, Chitose, Suzuki, Takehiro, Tomioka, Yoshihisa, Watanabe, Shun   +24 more
core   +1 more source

MOESM1 of miR-335-5p inhibits TGF-β1-induced epithelialâ mesenchymal transition in non-small cell lung cancer via ROCK1

, 2019
Additional file 1: Table S1. The sequences of primers involved in our study.
Wenwen Du, Haicheng Tang, Lei, Zhe, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu, Huang, Jian-An   +6 more
openaire   +1 more source

TGF-β1 signaling in kidney disease: From Smads to long non-coding RNAs

Non-coding RNA Research, 2017
Transforming growth factor-β1 (TGF-β1) has an essential role in the development of kidney diseases. However, targeting TGF-β1 is not a good strategy for fibrotic diseases due to its multifunctional characteristic in physiology. A precise therapeutic target maybe identified by further resolving the underlying TGF-β1 driven mechanisms in renal ...
Patrick Ming-Kuen Tang, Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Hui-Yao Lan, MD, PhD   +3 more
openaire   +3 more sources