Results 71 to 80 of about 166,365 (294)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion [PDF]

, 2014
Cancer progression is characterized by a complex reciprocity between neoplastic epithelium and adjacent stromal cells. In ductal carcinoma in situ (DCIS) of the breast, both reduced stromal decorin expression and myxoid stroma are correlated with ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Vlieghere, Elly, De Wever, Olivier, Denys, Hannelore, Lambein, Kathleen, Libbrecht, Louis, LIMAME, RIDHA, Van Bockstal, Mieke, Van den Broecke, Rudy, Van Gele, Mireille   +11 more
core   +6 more sources

The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC ActivationSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Transforming growth factor-β1 (TGF-β1) plays important roles in chronic liver diseases, including metabolic dysfunction–associated steatotic liver disease (MASLD). MASLD involves various biological processes including dysfunctional
Sai Wang, Frederik Link, Mei Han, Roohi Chaudhary, Anastasia Asimakopoulos, Roman Liebe, Ye Yao, Seddik Hammad, Anne Dropmann, Marinela Krizanac, Claudia Rubie, Laura Kim Feiner, Matthias Glanemann, Matthias P.A. Ebert, Ralf Weiskirchen, Yoav I. Henis, Marcelo Ehrlich, Steven Dooley   +17 more
doaj   +1 more source

Role of TGFbRII in myeloid cell mediated regenerative processes and fibroplasia [PDF]

, 2012
Tissue repair and fibrosis are controlled by the interaction of different cell lineages, their soluble factors and matrix signals. Recently, macrophages have been found to be crucial for proper tissue repair.
Ranjan, Rajeev
core  

Additional file 1: of Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells

, 2019
Table S1. hnRNP K interacting proteins identified in this study (DOCX 17 kb)
Li, Liping, Yan, Songxin, Zhang, Hua, Zhang, Min, Huang, Guofu, Chen, Miaojuan   +5 more
openaire   +1 more source

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer

Open Access Macedonian Journal of Medical Sciences, 2018
BACKGROUND: Papillary thyroid carcinoma (PTC) accounts for 80% of the thyroid malignancies that are characterised by slow growth and an excellent prognosis. Over-expression of SMAD4 protein restores TGF-β signalling, determines a strong increase in anti-proliferative effect and reduces invasive potential of tumour cells expressing it.AIM: The study ...
Ivanova, Koni, Manolova, Irena, Ignatova, Maria-Magdalena, Gulubova, Maya   +3 more
openaire   +4 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744. [PDF]

PLoS ONE, 2011
Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis.
John Martin, Robert H Jenkins, Rasha Bennagi, Aleksandra Krupa, Aled O Phillips, Timothy Bowen, Donald J Fraser   +6 more
doaj   +1 more source

Α-SMA Expression Increased Over Cell Passages and Decreased by Exogenous TGF-β1, in Vitro Studies on Myofibroblast Derived From Orbital Socket Contracture [PDF]

, 2018
Α-smooth muscle actin (α-SMA), a marker of myofibroblast, induces cytoskeleton reorganization, increases contractility and stimulates cell migration in TGF-β1 induced stress fibers.
Chairinnisa, E. S. (Elsa), Dewi, D. S. (Debby), Hernowati, T. E. (Tinny), Lirawati, D. (Diana), Sujuti, H. (Hidayat)   +4 more
core  

SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma [PDF]

, 2018
Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT).
Attisano, Balling, Basler, Belecky Adams, Bigot, Blobe, Burdette, Chantry, Chantry, Chantry, Chen, Crum, Crum, Crum, Derynck, Dressler, Eccles, Eccles, Eccles, Eccles, Eccles, Eccles, Eccles, Einicker-Lamas, Falb, Gilbert, Goodyer, Gruss, Gutwein, Hammerman, Hemmati-Brivanlou, Humes, Ichikawa, Karsenty, Kojima, Kou, Kuypers, Liu, Lodish, Massagué, Massagué, Massagué, Miyazono, Moch, Mutter, Nigam, Riddle, Robertson, Rosenblum, Santisteban, Schoen, Su, Tabata, ten Dijke, Tian, Truong, Van Themsche, Vanderhyden, Westphal, Wick, Winyard, Wrana, Wrana, Yang, Yi, Zhang, Zhang, Zhou, Zipori   +68 more
core   +1 more source