Results 71 to 80 of about 239,501 (262)

Immunization with TGF-β1 kinoids elicits TGF-β1 neutralizing IgG Abs.

, 2013
(A) Male BALB/c mice were i.p. injected with the TGF-β1 kinoids (50 μg in 0.2 mL), keyhole limpet hemocyanin (KLH, 50 μg in 0.2 mL) or an equal volume of phosphate-buffered saline, 2 weeks apart a total of four times.
Shuang Li (146392), Zhiming Hao (495949), Houqiang Su (495947), Yifei Lv (495946), Huiping Jiang (495948), Qiannan Zhang (495945), Xiaobao Fan (495944)   +6 more
core   +1 more source

TGF-β1 does not induce neutrophil migration.

, 2023
(A) Graph showing the percentage of PMNs that migrated in transwell assays in response to M4 TCM or varying doses of TGF-β1. (B) Representative endpoint images of underagarose assays of dHL-60 cells stained with Hoechst. Migration stimuli were (i) mHBSS,
Carole A. Parent (10582907), Craig N. Johnson (16954685), Lauren E. Hein (10582904), Gaurie Gunasekaran (16954682), Shuvasree SenGupta (7343309)   +4 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

TGF-β1-induced glutaminolysis accelerates endothelial migration and PP2A-Raf-MEK-ERK pathway is involved in this process.

, 2016
The cells were pretreated with U0126 (10μM) and OA (10 nM) for 30 minutes before TGF-β1 (10 ng/ml) stimulation and then cultured for 48 hours. (a) Cell migration was promoted by TGF-β1, and inhibition of PP2A-Raf-MEK-ERK pathway inhibited cells sprouting.
Yong Ning (726887), XuePing Lin (3112470), XiaoQing Li (3112467), YanYan Guo (3112464), ShuiMing Guo (3112476), MeiXue Chen (3112461), YuanJun Deng (3112473), Min Han (56772)   +7 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Additional file 2: of LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation

, 2019
Figure S2. Effect of miR-128-3p mimic and Sp1 silencing on the PVT1 overexpression-induced secretion of TGF-β1. Levels of TGF-β1 were measured using ELISA. *P 
Ling Yan (555222), Zhe Li (219258), Wen-mao Ding (6492620), Feng Cao (38032), Qing-yan Zhao (6492623)   +4 more
core   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Transforming growth factor beta-1 promotes migration and invasion of ovarian epithelial carcinoma cells through TRAF6-mediated activation of Notch3 signaling pathway

Zhongguo aizheng zazhi, 2018
Background and purpose: Abnormal expression and amplification of transforming growth factor beta 1 (TGF-β1) and Notch3 in ovarian carcinoma tissues are associated with metastasis and low survival rate, respectively.
周韵娇, 王婧姝, 梁　凡
doaj