Results 71 to 80 of about 202,654 (267)
Transforming Growth Factor-Beta1 in Diabetic Kidney Disease
Frontiers in Cell and Developmental Biology, 2020 Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Renin-angiotensin-aldosterone system (RAAS) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown efficacy in reducing the risk of ESRD.
Lijun Zhao, Yutong Zou, Fang Liu
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari +10 more
wiley +1 more source
TGF-β1-induced glutaminolysis accelerates endothelial migration and PP2A-Raf-MEK-ERK pathway is involved in this process. [PDF]
, 2016 The cells were pretreated with U0126 (10μM) and OA (10 nM) for 30 minutes before TGF-β1 (10 ng/ml) stimulation and then cultured for 48 hours. (a) Cell migration was promoted by TGF-β1, and inhibition of PP2A-Raf-MEK-ERK pathway inhibited cells sprouting.
Yong Ning (726887) +7 more
core +1 more source
Advanced Materials, EarlyView.Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma +15 more
wiley +1 more source
Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744. [PDF]
PLoS ONE, 2011 Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis.
John Martin +6 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le +4 more
wiley +1 more source
Tgf-β1 network in mammary epithelium in the absence of Rspo1. [PDF]
, 2016 A- Ingenuity Pathway Analysis performed using the 246 differentially expressed genes identified in the absence of Rspo1 on day-12 of pregnancy highlighted the Tgf-β1 network. Green and red colours indicate down and up-regulation, respectively.
Aude Ehanno (3112290) +7 more
core +1 more source
Advanced Science, EarlyView.In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu +7 more
wiley +1 more source
Anti-TGF-β1 antibody recognizes pm26TGF-β1. [PDF]
, 2015 The commercial anti-TGF-β1 antibody recognized the pm26TGF-β1 peptide, bound in PBMC surface, confirming that the TβRII has equally recognized both TGF-β1 and pm26TGF-β1 peptide.
Carlos Ueira-Vieira (788971) +12 more
core +1 more source
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source