Results 81 to 90 of about 166,365 (294)

Additional file 1: of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
Supplementary Notes. (PDF 107 kb)
Huipeng Li, Venkatraman, Lakshmi, Balakrishnan Narmada, White, Jacob, Hanry Yu, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells [PDF]

, 2014
BACKGROUND: Hard consistency, developed under the influence of tumor cell factors, is a characteristic feature of a breast tumor. Activation of resident fibroblasts leading to a myofibroblast phenotype is the principal feature that orchestrates this ...
Carla Urra, Jorge Martínez, Marcela Toyos, Nicolás Méndez, Nicolás Tobar, Patricio C Smith, Rodrigo Arancibia   +6 more
core   +1 more source

Additional file 1: Table S1. of No association between TGF-β1 polymorphisms and risk of nasopharyngeal carcinoma in a large North African case-control study

, 2016
Association of TGF-β1 gene polymorphisms with TNM stage. (DOCX 21 kb)
Khaali, Wafa, Moumad, Khalid, Driss, El Khalil Ben, Abdellatif Benider, Wided Ben Ayoub, Hamdi-Cherif, Mokhtar, Kada Boualga, Hassen, Elham, Marilys Corbex, Meriem Khyatti   +9 more
openaire   +1 more source

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]

, 2018
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J, Shen, Jie, Silverman, Richard M, Wang, Cuicui   +3 more
core   +3 more sources

Additional file 3: Table S2. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
Parameters settings for different models. (PDF 47 kb)
Huipeng Li, Venkatraman, Lakshmi, Balakrishnan Narmada, White, Jacob, Hanry Yu, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source

Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity

Advanced Functional Materials, EarlyView.
Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen, Zheyuan Miao, Gary Tom, Austin H. Cheng, Elizaveta Gusarova, Benjamen Zondag, Tianyi Wu, Dianoosh Kalhori, Boris Hinz, Milad Abolhasani, Alán Aspuru‐Guzik, Eugenia Kumacheva   +11 more
wiley   +1 more source

PKCα-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-β1

Journal of Experimental & Clinical Cancer Research, 2010
Background Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.
Chen Ying, Yu Guanzhen, Yu Danghui, Zhu Minghua   +3 more
doaj   +1 more source

Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis. [PDF]

PLoS ONE, 2011
Transforming growth factor-β1 (TGF-β1) signaling plays a key role in vertebrate development, homeostasis, and disease. Nuclear factor I-C (NFI-C) has been implicated in TGF-β1 signaling, extracellular matrix gene transcription, and tooth root development.
Dong-Seol Lee, Won-Joon Yoon, Eui Sic Cho, Heung-Joong Kim, Richard M Gronostajski, Moon-Il Cho, Joo-Cheol Park   +6 more
doaj   +1 more source