Results 91 to 100 of about 239,501 (262)

Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis

Journal of Experimental & Clinical Cancer Research, 2012
Background Transforming growth factor (TGF)-β is known to be produced by progressor tumors and to immobilize dendritic cells (DCs) within those tumors.
Imai Kazuhiro, Minamiya Yoshihiro, Koyota Souichi, Ito Manabu, Saito Hajime, Sato Yusuke, Motoyama Satoru, Sugiyama Toshihiro, Ogawa Jun-ichi   +8 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

The mRNA levels changes of TGF-β1, Col I, and Col III after TLP treatment.

, 2013
The groups were designed as Cell-Lv-TLP (HSFs transfected with recombinant lentivirus), Cell-Lv (HSFs transfected with control lentivirus ), Cell (HSFs without any treatment), Cell-Lv-TLP+TGF-β1 (HSFs transfected with recombinant lentivirus and ...
Chen Wang (88408), Xue Wang (102830), Danru Wang (283800), Yunliang Qian (283797), Jun Chen (4238), Yan Wo (283799), Rong Jin (201093)   +6 more
core   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Blood Indoxyl Sulfate and TGF-β1 Protein and mRNA Levels in Chronic Kidney Disease: Updated Insights

Acta Medica Iranica
Chronic kidney disease (CKD) is characterized by systemic inflammation and the accumulation of uremic toxins such as indoxyl sulfate (IS), which induces fibrogenic signaling via transforming growth factor-beta 1 (TGF-β1).
Farhad Nazarinasi, Siavash Gerayeshnejad, Nasrin Dashti, Khosrow Rahbar   +3 more
doaj   +1 more source

TIMP-1-GPI impacts TGF-β1 expression and processing.

, 2012
TGF-β1 can inhibit mesothelial cell migration and proliferation. MMP-9 and MMP-2 can proteolytically activate latent TGF-β1. Cell surface engineering with TIMP-1-GPI leads to a reduction in the expression and processing of latent TGF-β1 to its active ...
Elfriede Noessner (146689), Thomas Sitter (168211), Susanne Himmelein (168206), Peter J. Nelson (168215), Markus Wörnle (168201), Pankaj Goyal (156516), Matthias Sauter (168187), Susan Notohamiprodjo (168192), Andrea Ribeiro (168203), Roghieh Djafarzadeh (88033), Wolfgang Siess (168198)   +10 more
core   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

TGF-β1 induced IGFBP7 expression in HRPTECs.

, 2016
HRPTECs were incubated for 48 h with the indicated concentrations of TGF-β1 in serum-free medium. IGFBP7 mRNA expression was determined by real-time RT-PCR (A). The expression of IGFBP7 was normalized to that of GAPDH in the same cell extracts.
Masakazu Haneda (343591), Jun Watanabe (403029), Masatoshi Tateno (3179874), Yuichi Makino (3165276), Jun Honjyo (3179871), Yukihiro Fujita (3035949), Yumi Takiyama (3165279)   +6 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source