Results 101 to 110 of about 239,501 (262)

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

The TGF-β1 Signaling Pathway as an Attractive Target in the Fibrosis Pathogenesis of Sjögren’s Syndrome

Mediators of Inflammation, 2018
Transforming growth factor β1 (TGF-β1) plays a crucial role in the induction of fibrosis, often associated with chronic phases of inflammatory diseases contributing to marked fibrotic changes that compromise normal organ function.
Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Roberto Tamma, Domenico Ribatti, Sabrina Lisi   +5 more
doaj   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Latency-Associated Peptide Rapidly Upregulates Neuraminidase 3 in a Profibrotic Translation-Based Positive Feedback Loop

Cells
Fibrosis appears to be an out-of-control wound-healing response that drives a progressive formation of scar tissue in an organ. A key profibrotic cytokine, transforming growth factor beta-1 (TGF-β1), upregulates levels of the extracellular sialidase ...
Sumeen Kaur Gill, Richard H. Gomer
doaj   +1 more source

TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway

Cellular Physiology and Biochemistry, 2017
Background/Aims: Transforming growth factor-β1 (TGF-β1) plays a crucial role in chronic inflammation in various tissues, and is related to inflammation-caused organ fibrogenesis associated with the epithelial-mesenchymal transition (EMT) and the ...
Qing Chen, Wei Yang, Xixi Wang, Xueru Li, Shaopei Qi, Yong Zhang, Ming-Qing Gao   +6 more
doaj   +1 more source

The effect of TGF-β1 on the Smad signal pathway.

, 2016
(A) TGF-β1 upregulated the expression of Smad2/3. (B) Sim and Losinhibited the protein expression of Smad2/3 in the atrial CFs treated with TGF-β1.
Li-Juan Liu (293637), Kai Tang (138245), Gui-Hua Lu (3110931), Feng-Juan Yao (459532), Su-Hua Wu (459536), Yun-Jiu Cheng (459530), Zhe Xu (127066), Xiu-Ren Gao (3110928), Cheng-Gui Xu (3110934)   +8 more
core   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

LncRNA GASL1 is downregulated in chronic heart failure and regulates cardiomyocyte apoptosis

Cellular & Molecular Biology Letters, 2019
Background TGF-β1 contributes to chronic heart failure. It is known that lncRNA GASL1 can inactivate TGF-β1 in cancer biology. Methods All the participants were enrolled in the First People’s Hospital of Zhaoqing during the period June 2012 to June 2013.
Haihong Deng, Wenbo Ouyang, Li Zhang, Xiaoshan Xiao, Zhiyong Huang, Wendian Zhu   +5 more
doaj   +1 more source

TGF-β1 induces mitochondrial depolarization.

, 2015
A) Beas-2B cells stimulated with TGF-β1 and CCCP (positive controls) were stained with JC-1 for 15 min and analyzed by flow cytometric analysis. TGF-β1 treated cells showed decreased red fluorescence (mitochondrial depolarization).
Sarah G. Chu (705217), Danielle Morse (315479), Souheil El-Chemaly (705219), Chun Geun Lee (171084), Jin Woo Song (705216), Juan C. Osorio (504195), Ying Shi (115282), Avignat S. Patel (315473), Ivan O. Rosas (315478), Jack A. Elias (570371), Augustine M. K. Choi (39903), Kenji Mizumura (705218)   +11 more
core   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source