Results 101 to 110 of about 166,365 (294)

<p>DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway</p>

OncoTargets and Therapy, 2019
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the molecular mechanisms of TGF-β1-induced cSCC ...
Juan Zhang, Hui Jiang, Dan Xu, Wen-Juan Wu, Hong-Duo Chen, Li He   +5 more
openaire   +4 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

AFAP1 Is a Novel Downstream Mediator of TGF-β1 for CCN2 Induction in Osteoblasts.

PLoS ONE, 2015
BACKGROUND:CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function. CCN2 is induced by TGF-β1 and acts as a mediator of TGF-β1 induced matrix production in osteoblasts and Src is required for CCN2 induction by TGF-β1 ...
Youngjin Cho, Rachel Silverstein, Max T Geisinger, Stephen Martinkovich, Holly Corkill, Jess M Cunnick, Sonia L Planey, John A Arnott   +7 more
doaj   +1 more source

Effect of BMP-12, TGF-β1 and autologous conditioned serum on growth factor expression in Achilles tendon healing [PDF]

, 2018
Purpose: Achilles tendon ruptures are devastating and recover slowly and incompletely. There is a great demand for biomolecular therapies to improve recovery, yet little is understood about growth factors in a healing tendon.
Evans, Christopher, Flückiger, Rudolf, Heisterbach, Patricia, Majewski, Martin, Todorov, Atanas   +4 more
core  

Additional file 1: of High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response

, 2019
Patientsâ information summary. (DOCX 12 kb)
Ziklo, Noa, Huston, Wilhelmina, Kuong Taing, Timms, Peter   +3 more
openaire   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Additional file 1: of Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells

, 2019
Table S1. Sequences of RNAi for transfection. Table S2. Sequences of primer pairs for qPCR. Table S3. Sequences of ZEB1-AS1 probe for FISH. (DOCX 13 kb)
Gao, Ruxu, Zhang, Naiwen, Yang, Jianyu, Zhu, Yuyan, Zhang, Zhe, Wang, Jianfeng, Xu, Xiaolong, Li, Zeliang, Liu, Xiankui, Li, Zhenhua, Li, Jun, Kong, Chuize, Bi, Jianbin   +12 more
openaire   +1 more source

Sprayable Polymer Blends With Short‐Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
Adhesions’ high occurrence rates and high morbidity render them a critical challenge to be addressed. Current prevention methods, such as physical barriers, have many limitations, resulting in inconsistent safety and efficacy. This study demonstrates the potential for sprayable polymeric materials as an adhesion barrier.
Robert J. Morris III, Tejaswi Nori, Alex I. Halpern, Hannah LaPadula, Arthur V. Cresce, Sarah L. Wright, Anthony D. Sandler, Peter Kofinas   +7 more
wiley   +1 more source

KAJIAN EKSPRESI TGF-ββββ1, MMP-9, KOLAGEN TIPE-1, KOLAGEN TIPE-IV, GLOMERULOSKLEROSIS, INTERSTISIAL FIBROSIS, ALBUMINURIA PADA KEJADIAN NEFROTOKSIK DOXORUBICIN DAN NEFROPROTEKTIF PENTOXIFYLLIN DENGAN HEWAN COBA MENCIT GALUR SWISS JANTAN [PDF]

, 2010
Pemakaian Doxorubicin (DXR) dalam pengobatan kanker semakin meningkat, dengan meningkatnya morbiditas kanker. Efek nefrotoksik dari DXR masih menjadi masalah.
Purwanto, Bambang
core   +1 more source

The effect of oxidative stress and glucocorticoids on TGF-ß1 production in airway epithelial cells

, 2010
Transforming growth factor-β1 (TGF-β1) is implicated in inflammation and airway wall remodeling in inflammatory airway disease. Oxidative stress has also been implicated in the pathogenesis of inflammatory lung disorders. Reactive oxygen species (ROS),
Chou, Pai Chien, Chou, Pai Chien
core   +1 more source