Results 121 to 130 of about 202,654 (267)
TGF-β1, IL-6 and IL-17 mRNA expression of NRK-52E after glucose stimulation. [PDF]
, 2016 Relative TGF-β1 (A), IL-6 (B) and IL-17 (C) mRNA expression of non-stimulated NRK-52E (nc) and at different time points after stimulation by 25 mM glucose or 20 mM mannose as an osmotic control.
Stephanie Krämer (3165525) +4 more
core +1 more source
Advanced Science, EarlyView.Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang +8 more
wiley +1 more source
, 2001 Fibrosis is a disease where the normally transitory wound healing response enters a chronic state. Bleomycin and Adenovector models of pulmonary fibrosis have implicated TGF-β1 in this disease.
Galt, Thomas
core
Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling [PDF]
, 2014 Mesenchymal stem cells (MSCs) are multipotent adult stem cells that have regenerative capability and exert paracrine actions on damaged tissues. Since peritoneal fibrosis is a serious complication of peritoneal dialysis, we tested whether MSCs suppress ...
Ueno, Toshinori
core +1 more source
TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway
Cellular Physiology and Biochemistry, 2017 Background/Aims: Transforming growth factor-β1 (TGF-β1) plays a crucial role in chronic inflammation in various tissues, and is related to inflammation-caused organ fibrogenesis associated with the epithelial-mesenchymal transition (EMT) and the ...
Qing Chen +6 more
doaj +1 more source
Advanced Science, EarlyView.ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning +7 more
wiley +1 more source
Additional file 1: of LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation [PDF]
, 2019 Figure S1. ELISA analysis showed that PVT1 overexpression further up-regulated the Ang-II-induced secretion of TGF-β1, whereas PVT1 knockdown exerted the opposite effect. *P
Ling Yan (555222) +4 more
core +1 more source
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source
CCL22 and TGF-β1 expression in BC. [PDF]
, 2013 (A) Negative expression of TGF-β1 in BC (×200). (B) Weak expression of TGF-β1 in BC (×200). (C) Strong expression of TGF-β1 in BC (×200). (D) Negative expression of CCL22 in BC (×200). (E) Weak expression of CCL22 in BC (×200).
Mei-Jing Ren (466997) +5 more
core +1 more source
Advanced Science, EarlyView.PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu +17 more
wiley +1 more source