Results 141 to 150 of about 239,501 (262)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1

Tuberculosis and Respiratory Diseases, 2019
Background Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis.
Sang Hoon Lee, M.D., Ju Hye Shin, M.S., Mi Hwa Shin, B.S., Young Sam Kim, M.D., Ph.D., Kyung Soo Chung, M.D., Joo Han Song, M.D., Song Yee Kim, M.D., Ph.D., Eun Young Kim, M.D., Ph.D., Ji Ye Jung, M.D., Ph.D., Young Ae Kang, M.D., Ph.D., Joon Chang, M.D., Ph.D., Moo Suk Park, M.D., Ph.D.   +11 more
doaj  

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source

TGF-β1 interactome: Metastasis and beyond

, 2010
The ubiquitous cytokine transforming growth factor-β1 (TGF-β1) is one of the most potent metastatic inducers. Functional interactomic mapping using high-throughput proteomic and genomic data provides valuable insights into the regulation of tumor ...
Lacy, JN, Tsang, CS, Distel, RJ, Ricchiuti, V, Smejkal, GB, OhnoMachado, L, Samaranayake, LP, Kuo, WP, Perera, M, Smith, MG, Trachtenberg, AJ   +10 more
core  

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

Advanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo, Cheng‐Chen Hou, Wei Wang, Ya‐Xuan Zhu, Ling Li, Li‐Juan Liu, Chuan‐Jian Lu, Peng‐Fei Tu, Yang Liu, Rui‐Zhi Zhao, Ke‐Wu Zeng   +10 more
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source