Results 61 to 70 of about 239,501 (262)
Advanced Materials, EarlyView.Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner +10 more
wiley +1 more source
Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction
Advanced Materials, EarlyView.The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu +2 more
wiley +1 more source
Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744. [PDF]
PLoS ONE, 2011 Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis.
John Martin +6 more
doaj +1 more source
A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration
Advanced Materials Interfaces, EarlyView.The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani +2 more
wiley +1 more source
LRRC33 co-localizes with pro-TGF-β1 in MV4-11 and AML193 cells.
, 2019 (A) Flow cytometry of double-staining of fixed and permeabilized AML193 and MV4-11 cells. Cells were stained with Alexa488-conjugated LRRC33 and APC-conjugated pro-TGF-β1 mAbs before and after PMA stimulation.
Wenjiang Ma (731091) +3 more
core +1 more source
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2010 Background Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.
Chen Ying +3 more
doaj +1 more source
TGF-β1 mediates HG-induced DDR2 and collagen gene expression.
, 2019 (A-D) Inhibition of TGF-β1 abolished HG-induced collagen type I alpha 1 and DDR2 gene expression. Following pre-treatment of cells with TGF-β1 inhibitor, SB431542, for 1 h and subsequently with HG for 12 h, (A and B) collagen type I alpha 1 protein ...
Robert Monticone (8087270) +11 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
PLoS ONE, 2018 IntroductionFor immune cells transforming growth factor beta-1 (TGF-β1) can enhance or repress effector functions. Here, we characterize the effects of TGF-β1 on IgE-mediated and IL-33-mediated activation of primary murine mast cells derived from ...
David O Lyons +2 more
doaj +1 more source