Results 61 to 70 of about 166,365 (294)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

HIF‐1α modulates pancreatic cancer ECM proteins via the TGF‐β1/Smad signaling pathway introduction

Frontiers in Oncology
IntroductionPancreatic cancer is characterized by its aggressive nature and poor prognosis, ranking among the most lethal malignancies. The tumor microenvironment, particularly the extracellular matrix (ECM), plays a crucial role in cancer progression ...
Houle Guo, Houle Guo, Zhanxue Zhao, Linxun Liu   +3 more
doaj   +1 more source

MOESM3 of miR-335-5p inhibits TGF-β1-induced epithelialâ mesenchymal transition in non-small cell lung cancer via ROCK1

, 2019
Additional file 3: Table S2. Clinicopathological features of NSCLC tissues from 30 patients with non-lymph node metastasis and 30 patients with lymph node metastasi.
Wenwen Du, Haicheng Tang, Lei, Zhe, Jianjie Zhu, Yuanyuan Zeng, Zeyi Liu, Huang, Jian-An   +6 more
openaire   +1 more source

Mesenchymal stem cell-derived exosomes improve diabetes mellitus-induced myocardial injury and fibrosis via inhibition of TGF-β1/Smad2 signaling pathway

Cellular and Molecular Biology, 2019
The aim of this study is to investigate  the effect of mesenchymal stem cell (MSC)-derived exosomes on diabetes mellitus-induced myocardial injury, and the underlying mechanism. Thirty adult male Sprague Dawley rats were randomly assigned to three groups of ten rats each: normal control group, diabetic control group and MSC exosomes group.
Yuan, Lin, Fang, Zhang, Xiao-Fen, Lian, Wei-Qun, Peng, Chao-Yao, Yin   +4 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Additional file 6: of Autophagy enhances mesenchymal stem cell-mediated CD4+ T cell migration and differentiation through CXCL8 and TGF-β1

, 2019
Table S1. Primers used for qRT-PCR (DOCX 16 kb)
Cen, Shuizhong, Wang, Peng, Xie, Zhongyu, Yang, Rui, Li, Jinteng, Liu, Zhenhua, Wang, Shan, Wu, Xiaohua, Liu, Wenjie, Li, Ming, Tang, Su’an, Shen, Huiyong, Wu, Yanfeng   +12 more
openaire   +1 more source

Influence of thrombophlebitis on TGF-β1 and its signaling pathway in the vein wall.

Folia Histochemica et Cytobiologica, 2011
Extensive extracellular matrix remodeling of the vein wall is involved in varicose veins pathogenesis. This process is controlled by numerous factors, including peptide growth factors. The aim of the study was to evaluate influence of thrombophlebitis on TGF-β1 and its signaling pathway in the vein wall. TGF-β1 mRNAlevels, growth factor content and its
Radoslaw Kowalewski, Andrzej Malkowski, Marek Gacko, Krzysztof Sobolewski   +3 more
openaire   +5 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men [PDF]

, 2016
TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis through various mechanisms. The expression and function of TGF-β2 have not been investigated thoroughly in liver disease to date.
Abshagen, Kerstin, Angel, Peter, Bertran Rodríguez, Esther, Breitkopf-Heinlein, Katja, Coulouarn, Cédric, Dediulia, Tatjana, Dooley, Steven, Dropmann, Anne, Fabregat Romero, Isabel, Hess, Jochen, Janicot, Michel, Korhonen, Hanna, Meindl-Beinker, Nadja M., Piiper, Albrecht, Thomas, Maria, Weber, Susanne N.   +15 more
core   +2 more sources

LUAS DEFEK MENINGOKEL BERHUBUNGAN DENGAN KADAR TRANSFORMING GROWTH FACTOR β1 (TGF-β1)DAN INSULINE-LIKE GROWTH FACTOR-1 (IGF-1) DALAM TULANG

Jurnal Kedokteran Brawijaya, 2013
Meningocele pathogenesis is based on skull defect that occurs since the first three month of fertilization period. Through that defect, mening, cerebrospinal liquid, and cerebral parenchym is protruded. Meningocele can cause by folic aciddeficiency that had proved correlation with TGF-β1 and IGF-I level, both in maternal blood or baby rat’s skull.
openaire   +2 more sources