Results 1 to 10 of about 77,683 (117)

TRIM22 inhibits the proliferation of gastric cancer cells through the Smad2 protein [PDF]

Cell Death Discovery, 2021
TRIM22 is involved in tumorigenesis and development, but its mechanism is not clear. In this study, we investigated the expression and biological role of TRIM22 in gastric cancer.
Zhuqing Zhou, Wei Gao, Biao Yuan, Shun Zhang, Kaijing Wang, Tao Du   +5 more
doaj   +2 more sources

Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation

Cells, 2021
Transforming growth factor-β (TGF-β) has been identified as an inducer of hepatocyte epithelial–mesenchymal transition (EMT), which triggers liver fibrosis.
Sung-Min Kim, Won-Hee Hur, Byung-Yoon Kang, Sung-Won Lee, Pu-Reun Roh, Dong-Jun Park, Pil-Soo Sung, Seung-Kew Yoon   +7 more
doaj   +3 more sources

SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration [PDF]

Scientific Reports
Transforming growth factorβ (TGFβ) signaling regulates diverse aspects of vertebrate skeletal muscle tissue including differentiation, homeostasis, regeneration and pathogenic degeneration.
Yuki Yamasaki, Keita Sakamoto, Shunki Yashiro, Yutaro Kawa, Akiko Kondow, Atsushi Kubo, Keisuke Hitachi, Masafumi Inui   +7 more
doaj   +2 more sources

Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L [PDF]

Cell Journal, 2022
Objective: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region aswell. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type1 (PAI-1) which ...
hossein babaahmadi rezaei, alireza kheirolah, Faezeh Seif   +2 more
doaj   +1 more source

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer [PDF]

PeerJ, 2023
Objectives Liver fibrosis is a key stage in the progression of various chronic liver diseases to cirrhosis and liver cancer, but at present, there is no effective treatment.
Xiongqun Peng, Huixiang Yang, Lijian Tao, Jingni Xiao, Ya Zeng, Yueming Shen, Xueke Yu, Fei Zhu, Jiao Qin   +8 more
doaj   +2 more sources

Smad2/3 signaling involved in urotensin II-induced phenotypic differentiation, collagen synthesis and migration of rat aortic adventitial fibroblasts

Italian Journal of Medicine, 2023
Objective. To investigate whether Smad2/3 signaling is involved in urotensin II (UII) induced activation of aortic adventitial fibroblasts. Materials and Methods.
Weizhao Lin, Xu Yang, Fan Zheng, Jianshe Yang, Yonggang Zhang   +4 more
doaj   +1 more source

Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation

Cell Death Discovery, 2022
Hair follicle stem cells (HFSCs) are implicated in the formation of hair follicles and epidermis. This study aims to clarify the role of SMAD2 in regulating the differentiation of HFSCs, which is involved with Smurf2.
Bojie Lin, Dan Huang, Guanyu Lin, Yong Miao, Jin Wang, Zhexiang Fan, Zhiqi Hu   +6 more
doaj   +1 more source

miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

Molecular Therapy: Nucleic Acids, 2020
The study investigated the regulation of Smad2 by miR-18a and its role in preeclampsia (PE). Bioinformatics analysis showed that both Smad2 and Smad3 were the predicted targets for miR-18a.
Peng Xu, Zhilang Li, Yongqing Wang, Xin Yu, Xuan Shao, Yu-xia Li, Chun Peng, Yangyu Zhao, Yan-Ling Wang   +8 more
doaj   +1 more source

MiRNA-1202 promotes the TGF-β1-induced proliferation, differentiation and collagen production of cardiac fibroblasts by targeting nNOS.

PLoS ONE, 2021
BackgroundAtrial fibrillation (AF) is a clinically common arrhythmia that affects human health. Myocardial fibrosis serves as an important contributor to AF. Recently, miRNA-1202 have been reported to be up-regulated in AF.
Jingwen Xiao, Yan Zhang, Yuan Tang, Hengfen Dai, Yu OuYang, Chuanchuan Li, Meiqin Yu   +6 more
doaj   +1 more source

The role of the Smad2/3/4 signaling pathway in osteogenic differentiation regulation by ClC-3 chloride channels in MC3T3-E1 cells

Journal of Orthopaedic Surgery and Research, 2022
Background ClC-3 chloride channels promote osteogenic differentiation. Transforming growth factor-β1 (TGF-β1) and its receptors are closely related to ClC-3 chloride channels, and canonical TGF-β1 signaling is largely mediated by Smad proteins.
Xiaolin Lu, Weixu Li, Huan Wang, Meng Cao, Zuolin Jin   +4 more
doaj   +1 more source