Results 1 to 10 of about 2,208 (114)
Nuclear SMAD2 Restrains Proliferation of Glioblastoma [PDF]
Cellular Physiology and Biochemistry, 2015 Aims: Although TGFβ receptor signaling has been shown to play a role in regulation of the growth and metastasis of glioblastoma multiforme (GBM), the downstream pathway through either SMAD2 or SMAD3 has not been elucidated.
Yunhu Yu, Qishan Ran
doaj +3 more sources
Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma [PDF]
BMC Cancer, 2010 Background Transforming growth factor β (TGFβ) receptor signaling is closely associated with the invasion ability of gastric cancer cells. Although Smad signal is a critical integrator of TGFβ receptor signaling transduction systems, not much is known ...
Doi Yosuke +13 more
doaj +3 more sources
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif [PDF]
EMBO Journal, 2002 Transforming growth factor-beta (TGF-beta)/activin-induced Smad2/Smad4 complexes are recruited to different promoter elements by transcription factors, such as Fast-1 or the Mix family proteins Mixer and Milk, through a direct interaction between Smad2 and a common Smad interaction motif (SIM) in the transcription factors.
Stéphane Germain +2 more
exaly +5 more sources
Inhibition of SMAD2 expression prevents murine palatal fusion [PDF]
Developmental Dynamics, 2006 AbstractTransforming growth factor (TGF)‐beta 3 is known to regulate the disappearance of murine medial edge epithelium (MEE) during palatal fusion. Our previous studies showed that SMAD2, a TGF‐beta signaling mediator, was expressed and phosphorylated primarily in the MEE and that SMAD2 phosphorylation in the MEE was temporospatially regulated by TGF ...
Tadashi Yamamoto
exaly +3 more sources
Journal of Atherosclerosis and Thrombosis, 2009 Endoglin is a homodimeric transmembrane glycoprotein that has been demonstrated to affect transforming growth factor beta (TGF-beta) signaling and endothelial nitric oxide synthase (eNOS) expression by affecting SMAD proteins in vitro. Thus, in this study we stepped forward to elucidate whether endoglin is co-expressed with SMAD2, phosphorylated SMAD2 ...
Petr Nachtigal +2 more
exaly +4 more sources
Tumor Biology, 2016 The aim of this study was to explore the correlation between hepatocyte cell adhesion molecule (hepaCAM) and SMAD family member 2/3 (SMAD2/3) in bladder carcinoma, and the involvement of the SMAD2/3 pathway in hepaCAM-induced tumor apoptosis. Immunohistochemistry was used to measure hepaCAM and p-SMAD2/3 protein levels in bladder cancer tissues.
Chunli Luo, , Xiaorong Wang
exaly +3 more sources
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L [PDF]
Cell Journal, 2022 Objective: In addition to the carboxy region, Smad2 transcription factor can be phosphorylated in the linker region aswell. Phosphorylation of Smad2 linker region (Smad2L) promotes the expression of plasminogen activator inhibitor type1 (PAI-1) which ...
hossein babaahmadi rezaei +2 more
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miR-9500 Regulates Migration and Invasion of Lung Adenocarcinoma Cells by Targeting SMAD2
Zhongliu Fangzhi Yanjiu, 2023 Objective To explore the molecular mechanism underlying miR-9500 regulating the migration and invasion of lung adenocarcinoma cells by targeting SMAD2. Methods The core target genes of miR-9500 were screened out by bioinformatics analysis, and their GO ...
LI Fang, HAN Caili, WANG Li, SHEN Hui
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Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
Open Medicine, 2022 Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC).
Song Dongqiang +4 more
doaj +1 more source
Prostaglandin E2 modifies SMAD2 and promotes SMAD2–SMAD4 complex formation [PDF]
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2014 We report that PGE2 promotes Smad2-Smad4 complex formation and this phenomenon could be blocked by DIDS, an anion transporter inhibitor. Our data suggest that PGE2 had no effects on Smad2 phosphorylation, suggesting that PGE2-mediated Smad2-Smad4 complex formation is independent of TGF-β signaling and that PGE2 induced Smad2 modification which is ...
Chen, Yang, Chen, Chen, Andrey, Sorokin
openaire +2 more sources