Results 11 to 20 of about 81,731 (259)

MMP9 regulates osteogenesis and MMP2 expression through the TGF-β1/SMAD2/3 signaling pathway in lipopolysaccharide-induced osteoblasts [PDF]

Brazilian Journal of Medical and Biological Research
Matrix metalloproteinases (MMP) act as effectors and regulators in normal growth and development as well as in pathological processes. The gelatinases MMP2 and MMP9 exhibit similar structures and biological reactions.
Lei Li, Yang Yang, Ximei Lu, Hui Li
doaj   +3 more sources

SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration [PDF]

Scientific Reports
Transforming growth factorβ (TGFβ) signaling regulates diverse aspects of vertebrate skeletal muscle tissue including differentiation, homeostasis, regeneration and pathogenic degeneration.
Yuki Yamasaki, Keita Sakamoto, Shunki Yashiro, Yutaro Kawa, Akiko Kondow, Atsushi Kubo, Keisuke Hitachi, Masafumi Inui   +7 more
doaj   +2 more sources

GDF15 affects venous thrombosis by promoting EndMT through smad2/p-smad2 pathway

Thrombosis Journal, 2023
AbstractBackgroundEndothelial-to-mesenchymal transition (EndMT) is a pathophysiological change in the vascular endothelium commonly seen in the cardiovascular system. Elevated serum Growth differiention factor 15 (GDF15) has been reported in VTE patients, but the relationship and mechanism between GDF15, EndMT and VTE are still unclear.MethodsWe ...
Yeping Li, Huiqi Zhu, Wanghao Xin, Jiaoyan Wang, Chao Yan, Kejing Ying   +5 more
openaire   +3 more sources

Evidence for a Role of Smad3 and Smad2 in Stabilization of the Tumor-derived Mutant Smad2.Q407R [PDF]

Journal of Biological Chemistry, 2003
Transforming growth factor beta (TGF-beta) is a potent inhibitor of cell proliferation and the loss of responsiveness to TGF-beta may contribute to the development of human cancers. In hepatocellular carcinomas, the potential role of TGF-beta signaling as a tumor suppressor pathway can be illustrated by the presence of mutations in genes encoding TGF ...
Emmanuelle, Dumont, François, Lallemand, Céline, Prunier, Nathalie, Ferrand, André, Guillouzo, Bruno, Clément, Azeddine, Atfi, Nathalie, Théret   +7 more
openaire   +2 more sources

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling [PDF]

Journal of Biological Chemistry, 1997
Mothers against Dpp-related or Smad proteins are essential components of serine/threonine kinase receptor signaling pathways that are regulated by phosphorylation. Recently, it was demonstrated that Smad2 interacts transiently with and is a direct substrate of the transforming growth factor-beta (TGF-beta) type I receptor, TbetaRI.
S, Abdollah, M, Macías-Silva, T, Tsukazaki, H, Hayashi, L, Attisano, J L, Wrana   +5 more
openaire   +2 more sources

Analysis of the Smad2 gene in hematological malignancies [PDF]

Leukemia, 1998
A total of 34 leukemia and lymphoma samples (17 clinical samples and 17 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation polymorphism (RT-PCR-SSCP) analysis. Nine of the 34 samples had 18q chromosomal abnormalities.
T, Ikezoe, S, Takeuchi, M, Kamioka, M, Daibata, I, Kubonishi, H, Taguchi, I, Miyoshi   +6 more
openaire   +2 more sources

MicroRNA26a inhibits hyperplastic scar formation by targeting Smad2

Di-san junyi daxue xuebao, 2020
Objective To investigate the expression of microRNA-26a (mir-26a) and its target gene mothers against decapentaplegic homolog 2 (Smad2) in hypertrophic scar (HS) and explore their possible roles in HS formation.
WU Yangyang, CAO Ling, ZHANG Xia, QI Jun
doaj   +1 more source

SMAD2 inhibits pyroptosis of fibroblast-like synoviocytes and secretion of inflammatory factors via the TGF-β pathway in rheumatoid arthritis

Arthritis Research & Therapy, 2023
Objective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. Over-activation of fibroblast-like synoviocytes is responsible for the hyperplasia of synovium and destruction of cartilage and bone and pyroptosis of FLS plays a key role ...
Xingxing Mao, Weijie Wu, Yunyi Nan, Weiwei Sun, Youhua Wang   +4 more
doaj   +1 more source

An N-terminally truncated Smad2 protein can partially compensate for loss of full-length Smad2 [PDF]

Biochemical Journal, 2008
TGFβ (transforming growth factor β) superfamily signalling is critical both for early embryonic development and later for tissue homoeostasis in adult organisms. The use of gene-disruption techniques in mice has been essential to understanding the functional roles of the components of the pathways downstream of TGFβ superfamily ligands, in particular ...
Das, Debipriya, Randall, Rebecca A, Hill, Caroline S   +2 more
openaire   +3 more sources

Smad2 inhibition of MET transcription potentiates human vascular smooth muscle cell apoptosis

Atherosclerosis Plus, 2021
Background: Vascular smooth muscle cell (SMC) apoptosis is involved in major cardiovascular diseases. Smad2 is a transcription factor implicated in aortic aneurysm. The molecular mediators of Smad2-driven SMC apoptosis are not well defined.
Xiujie Xie, Takuro Shirasu, Lian-Wang Guo, K. Craig Kent   +3 more
doaj   +1 more source