Results 21 to 30 of about 81,731 (259)
Molecular Therapy: Nucleic Acids, 2020 The study investigated the regulation of Smad2 by miR-18a and its role in preeclampsia (PE). Bioinformatics analysis showed that both Smad2 and Smad3 were the predicted targets for miR-18a.
Peng Xu +8 more
doaj +1 more source
Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation
Cell Death Discovery, 2022 Hair follicle stem cells (HFSCs) are implicated in the formation of hair follicles and epidermis. This study aims to clarify the role of SMAD2 in regulating the differentiation of HFSCs, which is involved with Smurf2.
Bojie Lin +6 more
doaj +1 more source
Animal Cells and Systems, 2020 Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this ...
Zobia Umair +9 more
doaj +1 more source
Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region [PDF]
Nature Communications, 2013 Smad2/3-mediated transforming growth factor β signalling and the Ras-Raf-Mek-Erk cascade have important roles in stem cell and development and tissue homeostasis. However, it remains unknown whether Raf kinases directly crosstalk with Smad2/3 signalling and how this would regulate embryonic development.
Liu, Xingfeng +6 more
openaire +2 more sources
Journal of Orthopaedic Surgery and Research, 2022 Background ClC-3 chloride channels promote osteogenic differentiation. Transforming growth factor-β1 (TGF-β1) and its receptors are closely related to ClC-3 chloride channels, and canonical TGF-β1 signaling is largely mediated by Smad proteins.
Xiaolin Lu +4 more
doaj +1 more source
Smad2 Positively Regulates the Generation of Th17 Cells* [PDF]
Journal of Biological Chemistry, 2010 Development of Foxp3(+) regulatory T cells and pro-inflammatory Th17 cells from naive CD4(+) T cells requires transforming growth factor-β (TGF-β) signaling. Although Smad4 and Smad3 have been previously shown to regulate Treg cell induction by TGF-β, they are not required in the development of Th17 cells.
Martinez, G +9 more
openaire +3 more sources
Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. [PDF]
PLoS Genetics, 2016 TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs.
Weiguang Wang +5 more
doaj +1 more source
Italian Journal of Medicine, 2023 Objective. To investigate whether Smad2/3 signaling is involved in urotensin II (UII) induced activation of aortic adventitial fibroblasts. Materials and Methods.
Weizhao Lin +4 more
doaj +1 more source
Calmodulin Differentially Modulates Smad1 and Smad2 Signaling [PDF]
Journal of Biological Chemistry, 2000 The members of the Smad protein family are intracellular mediators of transforming growth factor beta (TGF-beta) signaling. Smad1 transduces bone morphogenetic protein signals, inducing formation of ventral mesoderm in Xenopus embryos, whereas Smad2 transduces activin/TGF-beta signals, generating dorsal mesoderm. Calmodulin directly binds to many Smads
A, Scherer, J M, Graff
openaire +2 more sources
SMAD2 Promotes Myogenin Expression and Terminal Myogenic Differentiation [PDF]
Development, 2020 ABSTRACT SMAD2 is a transcription factor whose activity is regulated by members of the Transforming Growth Factor beta (TGFβ) superfamily. While activation of SMAD2 and SMAD3 downstream of TGFβ or myostatin signaling is known to inhibit myogenesis, we find that SMAD2 in the absence of TGFβ signaling promotes terminal ...
Émilie Lamarche +5 more
openaire +3 more sources