SARS‐CoV‐2 N Protein Induces Acute Kidney Injury via Smad3‐Dependent G1 Cell Cycle Arrest Mechanism
Advanced Science, 2022 COVID‐19 is infected by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and can cause severe multiple organ injury and death. Kidney is one of major target organs of COVID‐19 and acute kidney injury (AKI) is common in critically ill COVID‐19
Hu Dingwen, Kailang Wu, Hui Y Lan
exaly +2 more sources
Mutations in Protein-Binding Hot-Spots on the Hub Protein Smad3 Differentially Affect Its Protein Interactions and Smad3-Regulated Gene Expression [PDF]
PLoS ONE, 2011 Hub proteins are connected through binding interactions to many other proteins. Smad3, a mediator of signal transduction induced by transforming growth factor beta (TGF-β), serves as a hub protein for over 50 protein-protein interactions.
Michael Abbott Newton +2 more
exaly +2 more sources
Mechanistic study of Shenge powder on myocardial hypertrophy and cardiac lymphatic intervention in TAC-induced mouse models [PDF]
Frontiers in PharmacologyPurposeTo investigate the therapeutic effect and mechanism of Shenge Powder (SGS) on myocardial hypertrophy and cardiac lymphangiogenesis using a transverse aortic constriction (TAC) mouse model and a TNF-α-induced lymphatic endothelial cell (LEC ...
Hua Fan +9 more
doaj +2 more sources
Effects of exosomes of mesenchymal stem cells on cholesterol-induced hepatic fibrogenesis [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Free cholesterol in the diet can cause liver fibrosis by accumulating in Hepatic stellate cells (HSCs). The rate of mortality of this disease is high worldwide and there is no definite remedy for it, but might be treated by anti-fibrotic ...
Mojtaba Rashidi +6 more
doaj +1 more source
陆军军医大学学报, 2022 Objective To investigate the effect of Smad3 on the apoptosis and autophagy of pancreatic cancer cells Panc-1 and BxPC-3, in order to preliminarily verify the effect of Smad3 expression in the progression of pancreatic cancer.
ZHANG Xudong +4 more
doaj +1 more source
BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. [PDF]
PLoS ONE, 2009 BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta)
Huchun Li +4 more
doaj +1 more source
Bone Reports, 2022 Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar +12 more
doaj +1 more source
Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer [PDF]
PeerJ, 2023 Objectives Liver fibrosis is a key stage in the progression of various chronic liver diseases to cirrhosis and liver cancer, but at present, there is no effective treatment.
Xiongqun Peng +8 more
doaj +2 more sources
Role of C-Reactive Protein in Kidney Diseases
Kidney Diseases, 2022 Background: C-reactive protein (CRP) is an acute phase protein and has been found to be a risk factor for acute renal injury (AKI) and chronic kidney diseases (CKD). However, role and mechanisms of CRP in AKI and CKD remain largely unclear.
Jiaxiao Li +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The dairy cattle suffer from severe liver dysfunction during the pathogenesis of ketosis. The Ufm1 conjugation system is crucial for liver development and homeostasis.
Fanghui Chen +6 more
doaj +1 more source