Results 11 to 20 of about 40,465 (206)

Identification and Expression Characterization of the Smad3 Gene and SNPs Associated with Growth Traits in the Hard Clam (Meretrix meretrix)

Fishes, 2021
It has been demonstrated that the sekelsky mothers against decapentaplegic homolog 3 (Smad3) plays an important role in the growth and development of vertebrates. However, little is known about the association between the Smad3 gene and the growth traits
Lulu Fu, Qiudie Chi, Yongbo Bao, Hanhan Yao, Zhihua Lin, Yinghui Dong   +5 more
doaj   +1 more source

TGF-β/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation. [PDF]

PLoS ONE, 2014
Atherosclerotic-associated diseases are the leading cause of death in the United States. Despite recent progress, interventional treatments for atherosclerosis can be complicated by restenosis resulting from neo-intimal hyperplasia.
Xudong Shi, Daniel DiRenzo, Lian-Wang Guo, Sarah R Franco, Bowen Wang, Stephen Seedial, K Craig Kent   +6 more
doaj   +1 more source

Syndecan-1 Amplifies Ovalbumin-Induced Airway Remodeling by Strengthening TGFβ1/Smad3 Action

Frontiers in Immunology, 2021
Syndecan-1 (SDC-1) is a transmembrane proteoglycan of heparin sulfate that can regulate various cell signal transduction pathways in the airway epithelial cells and fibroblasts.
Dong Zhang, Xin-rui Qiao, Wen-Jing Cui, Jin-tao Zhang, Yun Pan, Xiao-fei Liu, Liang Dong, Liang Dong   +7 more
doaj   +1 more source

Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5′ Untranslated Region

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis.
Xiujie Xie, Go Urabe, Lynn Marcho, Corey Williams, Lian‐Wang Guo, K. Craig Kent   +5 more
doaj   +1 more source

SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells

Stem Cell Research, 2020
SIPA1, a GTPase activating protein that negatively regulates Ras-related protein (Rap), is a potential modulator of tumor metastasis and recurrence. In this study, we first showed that SIPA1 facilitated the stemness features of breast cancer cells, such ...
Ning Wang, Jun Weng, Jing Xia, Yangjin Zhu, Qiongrong Chen, Die Hu, Xue Zhang, Rui Sun, Jueping Feng, Nagahiro Minato, Yiping Gong, Li Su   +11 more
doaj   +1 more source

Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion

Mediators of Inflammation, 2016
The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study.
Umme Salma, Min Xue, Md Sayed Ali Sheikh, Xiaoming Guan, Bin Xu, Aiqian Zhang, Lihua Huang, Dabao Xu   +7 more
doaj   +1 more source

Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer

Respiratory Research, 2018
Background This study investigated the function of SMAD3 (SMAD family member 3) in regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was employed to detect SMAD3 expression in cancer tissues along with normal tissues ...
Zhe Qian, Qiankun Zhang, Ying Hu, Tongmei Zhang, Jie Li, Zan Liu, Hua Zheng, Yuan Gao, Wenyun Jia, Aimin Hu, Baolan Li, Jiqing Hao   +11 more
doaj   +1 more source

Lentiviral reporter constructs for fluorescence tracking of the temporospatial pattern of Smad3 signaling

BioTechniques, 2007
Canonical TGF-β is involved in cell differentiation, tissue maintenance, and wound healing, but also plays a central role in the pathogenesis of diseases such as cancer.
Christina H. Stuelten, Anil K. Kamaraju, Lalage M. Wakefield, Anita B. Roberts   +3 more
doaj   +1 more source

Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy.

PLoS ONE, 2019
Diabetic nephropathy (DN) is among the most serious complications of diabetes mellitus, and often leads to end-stage renal disease ultimately requiring dialysis or renal transplantation. The loss of podocytes has been reported to have a role in the onset
Akiko Sakurai, Hiroyuki Ono, Arisa Ochi, Motokazu Matsuura, Sakiya Yoshimoto, Seiji Kishi, Taichi Murakami, Tatsuya Tominaga, Kojiro Nagai, Hideharu Abe, Toshio Doi   +10 more
doaj   +1 more source

TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes

Toxins, 2017
T-2 toxin can cause damage to the articular cartilage, but the molecular mechanism remains unclear. By employing the culture of rat chondrocytes, we investigated the effect of the TGF-β1/Smad3 signaling pathway on the damage to chondrocytes induced by T ...
Yang Li, Ning Zou, Jing Wang, Ke-Wei Wang, Fu-Yuan Li, Fu-Xun Chen, Bing-Yu Sun, Dian-Jun Sun   +7 more
doaj   +1 more source