Results 1 to 10 of about 55,423 (162)
EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis
The Journal of Clinical Investigation, 2022 SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that govern SMAD3 activation.
Changsheng Huang +15 more
doaj +2 more sources
Advanced Science, 2021 Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of lysine acetyltransferase 6A (KAT6A).
Bo Yu +9 more
doaj +2 more sources
Kidney Diseases, 2021 Background: Transforming growth factor-β (TGF-β)/Smad signaling is the central mediator in renal fibrosis, yet its functional role in acute kidney injury (AKI) is not fully understood.
Qin Yang +7 more
doaj +2 more sources
Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition
Advanced Science, 2023 Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)‐induced FSGS via Smad3‐dependent podocyte‐mesenchymal transition.
Qiong‐ Dan Hu +9 more
doaj +2 more sources
SARS‐CoV‐2 N Protein Induces Acute Kidney Injury via Smad3‐Dependent G1 Cell Cycle Arrest Mechanism
Advanced Science, 2022 COVID‐19 is infected by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and can cause severe multiple organ injury and death. Kidney is one of major target organs of COVID‐19 and acute kidney injury (AKI) is common in critically ill COVID‐19
Wenbiao Wang +10 more
doaj +2 more sources
Radiology and Oncology, 2019 Cervical cancer is one of the most frequent malignancies among females worldwide. Increasing evidence have indicated the participation of long noncoding RNAs (lncRNAs) in the progression and metastasis of cervical cancer.
Chang Qing-Qing +3 more
doaj +2 more sources
USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer
Cell Death and Disease, 2021 USP7, one of the most abundant ubiquitin-specific proteases (USP), plays multifaceted roles in many cellular events, including oncogenic pathways. Accumulated studies have suggested that USP7, through modulating the MDM2/MDMX-p53 pathway, is a promising ...
Yu-Ting Huang +9 more
doaj +2 more sources
Regenerative Therapy, 2022 Background: Gastric cancer (GC) progression is related with gene regulations. Objectives: This study explored underlying regulatory axis of circRNA PVT1 (circPVT1) in GC. Methods: GC cell lines were detected for circPVT1 expression with the normal mucous
Huanqin Li +5 more
doaj +2 more sources
陆军军医大学学报, 2022 Objective To investigate the effect of Smad3 on the apoptosis and autophagy of pancreatic cancer cells Panc-1 and BxPC-3, in order to preliminarily verify the effect of Smad3 expression in the progression of pancreatic cancer.
ZHANG Xudong +4 more
doaj +1 more source
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
doaj +1 more source