Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]
, 2018 The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M +3 more
core +2 more sources
Autocrine TGF-β Induces Epithelial to Mesenchymal Transition in Human Amniotic Epithelial Cells
Cell Transplantation, 2013 Human amniotic epithelial cells (hAECs) have been the object of intense research due to their potential therapeutic use. In this paper, we present molecular evidence of a bona fide epithelial to mesenchymal transition (EMT) undergone by hAECs.
Antonia Alcaraz +7 more
doaj +1 more source
Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay. [PDF]
PLoS ONE, 2011 It is generally assumed that T cells do not produce active TGF-β since active TGF-β as measured in supernatants by ELISA without acidification is usually not detectable. However, it is possible that active TGF-β from T cells may take a special form which
Takatoku Oida, Howard L Weiner
doaj +1 more source
Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
core +1 more source
Editorial Special Issue TGF-Beta/BMP Signaling Pathway
Cells, 2020 The transforming growth factor β (TGF-β) superfamily plays key roles in development and tissue homeostasis, controlling the maintenance and regeneration of mature tissues [...]
Isabel Fabregat +2 more
doaj +1 more source
TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy
Frontiers in Immunology, 2022 Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes, such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides, TGF-β plays a vital role in diseases, including cancer.
Ming Yi +6 more
doaj +1 more source
Lumican promotes joint fibrosis through TGF‐β signaling
FEBS Open Bio, 2020 Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules.
Dahai Xiao +8 more
doaj +1 more source
Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
Advanced Science, 2022 Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang +11 more
doaj +1 more source
Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 [PDF]
, 2018 Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic ...
A Dutta +65 more
core +2 more sources
Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
Frontiers in Oncology, 2018 The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of different cellular processes that are essential for tissue and organ homeostasis.
Isabel Fabregat +4 more
doaj +1 more source