Results 41 to 50 of about 13,045 (219)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

Molecular Oncology
Paired related homeobox 1 (PRRX1) is an inducer of epithelial‐to‐mesenchymal transition (EMT) in different types of cancer cells. We detected low PRRX1 expression in nevus but increased levels in primary human melanoma and cell lines carrying the ...
Josep R. Ferreres, Antònia Vinyals, Rafael Campos‐Martin, Roderic Espín, Sebastian Podlipnik, Raquel Ramos, Esther Bertran, Cristina Carrera, Joaquim Marcoval, Josep Malvehy, Isabel Fabregat, Susana Puig, Àngels Fabra   +12 more
doaj   +1 more source

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

Cellular Physiology and Biochemistry, 2015
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse ...
Yinan Shen, Yongpeng Wei, Zhouchong Wang, Yingying Jing, Haiguan He, Jianyong Yuan, Rong Li, Qiudong Zhao, Lixin Wei, Tian Yang, Junhua Lu   +10 more
doaj   +1 more source

TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression. [PDF]

PLoS ONE, 2012
The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor ...
Sun O Park, Mukesh Kumar, Sanjeev Gupta
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression

Cell Death and Disease
Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver ...
Josep Amengual, Ania Alay, Javier Vaquero, Ester Gonzalez-Sanchez, Esther Bertran, Aránzazu Sánchez, Blanca Herrera, Kathleen Meyer, Mate Maus, Manuel Serrano, María Luz Martínez-Chantar, Isabel Fabregat   +11 more
doaj   +1 more source

Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours

Frontiers in Bioengineering and Biotechnology
During wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g., chronification and diabetic foot ulcer) has proven very successful.
J. Stelling-Férez, J. Stelling-Férez, J. M. Puente-Cuadrado, V. Álvarez-Yepes, M. Alcaraz, M. Alcaraz, E. Tristante, I. Hernández-Mármol, I. Mompeán-Egea, A. M. García-Hernández, A. M. García-Hernández, F. J. Nicolás   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Decoding tumor–stroma interactions: from molecular crosstalk to therapeutic targets

FEBS Open Bio
With this “In the Limelight: Tumor‐Stroma Interactions” special issue, FEBS Open Bio aims to highlight the relevance of the tumor stroma cells, and their interactions with the tumor cells, in the progression of cancer.
Isabel Fabregat
doaj   +1 more source