Results 41 to 50 of about 2,112,620 (360)

TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]

, 2018
A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L, Chen, Yvonne Y, Hou, Andrew J, Lorenzini, Michael H, Zah, Eugenia   +4 more
core   +1 more source

Transforming growth factor-β: Biology and application to cancer therapy [PDF]

Archive of Oncology, 2009
Transforming growth factor-β (TGF-β), an extensively investigated cytokine, plays a very important role in promoting the spread of cancers in the body, and can play a direct role in facilitating metastasis.
Ivanović Vesna
doaj   +1 more source

KADAR TGF-β1 PLASMA DAN LIMFOSIT-T CD4+DI PENDERITA YANG TERINFEKSI HIV STADIUM I

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2018
HIV infection and AIDS have been spread throughout the world and the number of patients continues to increase from year to year.Indonesia is one of the countries with quite a high increase in the incidence of HIV and AIDS. The absolute number of CD4+T-lymphocytesand percentage in HIV-infected patients can be used to determine the stage of the disease ...
Albertina, Retnowati, Endang, Astha, Erwin   +2 more
openaire   +2 more sources

Hubungan Kadar TGF-β1 dan IFN-ɣ dengan Indeks Kronisitas Nefritis Lupus

Jurnal Kedokteran Brawijaya, 2013
Meskipun perbaikan penatalaksanaan terapi telah dilakukan dalam dua dekade terakhir , tetapi prognosis nefritis lupus tetap  tidak  memuaskan.  Oleh  karena  itu  diperlukan  suatu  biomarker  yang  dapat  menggambarkan  aktivitas  penyakit. Penelitian ini  dilakukan untuk untuk melihat peran TGF-β1 urin dan IFN-ɣ  urin sebagai ...
Indah Jayani, Kusworini Handono, Agustina Tri E   +2 more
openaire   +2 more sources

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]

, 2016
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley, A K Miles, A Kakizuka, B Terris, BR Henderson, C Gurrieri, C Johnson, CD Morrison, CH Heldin, D G Powe, D J Boocock, DG Altman, DR Principe, G Hulman, G Jin, G van Schalkwyk, H de Thé, H Son, HK Lin, J Borrow, J Hulman, J Massagué, J Massagué, JJ Christiansen, JP Thiery, Jr McCarty KS, JYH Chan, L Kubiczkova, M E Buczek, M Mazza, MG Mathieu, P Salomoni, PM Siegel, R C Rees, R Derynck, R Parkinson, RL Camp, S Grünert, S Lamouille, S Nisole, T Regad, T Regad, V Lallemand-Breitenbach, W Green, WC Yuan, Y Katakura   +45 more
core   +1 more source

TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

Bone Research, 2016
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling has fundamental roles in both embryonic skeletal development and postnatal bone homeostasis.
Mengrui Wu, Guiqian Chen, Yi-Ping Li
semanticscholar   +1 more source

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

Frontiers in Pharmacology, 2022
A ubiquitously expressed cytokine, transforming growth factor-beta (TGF-β) plays a significant role in various ongoing cellular mechanisms. The gain or loss-of-function of TGF-β and its downstream mediators could lead to a plethora of diseases includes ...
A. B. Baba, B. Rah, G. Bhat, I. Mushtaq, Sabra Parveen, Rukhsana Hassan, Mahrukh Hameed Zargar, D. Afroze   +7 more
semanticscholar   +1 more source

Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. [PDF]

PLoS ONE, 2011
BACKGROUND: Neuroendocrine activation and local mediators such as transforming growth factor-β₁ (TGF-β₁) contribute to the pathobiology of cardiac hypertrophy and failure, but the underlying mechanisms are incompletely understood.
Michael Huntgeburth, Klaus Tiemann, Robert Shahverdyan, Klaus-Dieter Schlüter, Rolf Schreckenberg, Marie-Luise Gross, Sonja Mödersheim, Evren Caglayan, Jochen Müller-Ehmsen, Alexander Ghanem, Marius Vantler, Wolfram H Zimmermann, Michael Böhm, Stephan Rosenkranz   +13 more
doaj   +1 more source

A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes

Cells, 2022
Nephronectin (NPNT) is an extracellular matrix protein in the glomerular basement membrane that is produced by podocytes and is important for the integrity of the glomerular filtration barrier. Upregulated transforming growth factor β (TGF-β) and altered
Nina Sopel, Alexandra Ohs, Mario Schiffer, Janina Müller-Deile   +3 more
doaj   +1 more source

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]

, 2014
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen, Karin, Michael, Suddason, Tesha, Wu, Xuefeng   +5 more
core   +2 more sources