Results 61 to 70 of about 320,405 (317)

NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts

Signal Transduction and Targeted Therapy
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment.
Josep Amengual, Ester Gonzalez-Sanchez, Mariana Yáñez-Bartolome, Laura Sererols-Viñas, Aashreya Ravichandra, Celia Guiton, Noel P. Fuste, Ania Alay, Sara Hijazo-Pechero, Beatriz Martín-Mur, Marta Gut, Anna Esteve-Codina, Ana Cantos-Cortes, Rut Espinosa-Sotelo, Emilio Ramos, Teresa Serrano, Mariona Calvo, Berta Laquente, Joana Ferrer, Gabriel Pons, Andrés Mendez-Lucas, Steven Dooley, Sumera I. Ilyas, Marie Vallette, Lynda Aoudjehane, Marie Lequoy, Laura Fouassier, Cédric Coulouarn, Silvia Affò, Alexander Scheiter, Diego F. Calvisi, Tian V. Tian, Isabel Fabregat, Javier Vaquero   +33 more
doaj   +1 more source

TGF-β-induced growth inhibition in B-cell lymphoma correlates with Smad1/5 signalling and constitutively active p38 MAPK

BMC Immunology, 2010
Background Cytokines of the transforming growth factor β (TGF-β) superfamily exert effects on proliferation, apoptosis and differentiation in various cell types. Cancer cells frequently acquire resistance to the anti-proliferative signals of TGF-β, which
Hilden Vera I, Huse Kanutte, Bakkebø Maren, Smeland Erlend B, Oksvold Morten P   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

ATBF1 Participates in Dual Functions of TGF-β via Regulation of Gene Expression and Protein Translocalization

Biomolecules, 2020
TGF-β is a critical cytokine to regulate multiple pathophysiological functions. For tumor development and progression, TGF-β was reported to play dual functions as a tumor suppressor and epithelial-mesenchymal transition (EMT) inducer.
Mei Li, Anqi Zhang, Yanan Zheng, Jiajing Li, Jiyuan Zhao   +4 more
doaj   +1 more source

TGF-β expression on different suturing technique for abdominal skin wound closure in rats [PDF]

, 2021
Imam Sofii, Ratna Sari Kalembu, Aditya Rifqi Fauzi, Firdian Makrufardi, Akhmad Makhmudi   +4 more
openalex   +1 more source

Additional file 5: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Figure S3. The AHNAK expression in HCCLM3 and HCCLM3-siAHNAK cells. Western blot showed that the expression of AHNAK after transfecting the short interfering RNA to HCCLM3. (PDF 152 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

Cell Reports, 2019
Summary: Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor β (TGF-β).
Panagiotis Papoutsoglou, Yutaro Tsubakihara, Laia Caja, Anita Morén, Paris Pallis, Adam Ameur, Carl-Henrik Heldin, Aristidis Moustakas   +7 more
doaj   +1 more source

Additional file 1: of MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2

, 2019
Table S1. Mouse primers for qRT-PCR. (DOCX 15 kb)
Liu, Yang, Feng, Lu, Xu, Jia, Yang, Zhengmeng, Wu, Tianyi, Zhang, Jiajun, Shi, Liu, Zhu, Dahai, Zhang, Jinfang, Li, Gang   +9 more
openaire   +1 more source

Additional file 7: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Table S2. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Up-regulated) (DOCX 43 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source