Results 71 to 80 of about 2,112,620 (360)

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. [PDF]

, 2017
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells.
A Alcami, A Moravej, AA Sulaiman, AB Roberts, AM Bilate, AP Hinck, B Blankenhaus, CAM Finney, CJ Johnston, CJC Johnston, D Onichtchouk, DE Elliott, DQ Tran, DV Sawant, E Bettelli, E Schmitt, E Willems, G Benichou, G Proetzel, GI Patterson, GJ Inman, HJ McSorley, HJ McSorley, I Tesseur, IB Robertson, J Groppe, J Tang, JC Marie, JD Fontenot, JE Zuniga, JP Hewitson, JR Dasch, JR Grainger, L Chen, L Zhou, LP Sanford, M Estevez, M Taylor, M Veldhoen, M Zdichavsky, MG Cull, MJ Beall, MM Villarreal, MO Li, MO Li, MS Wilson, N Gomez-Escobar, N Marek-Trzonkowska, ND Jones, PF Mercer, R Zavala-Gongora, RE Billingham, RM Maizels, RM Maizels, S Deep, S Radaev, S Rausch, SK Chauhan, T Huang, T Huang, W Chen, XO Yang, Y Liu, Y Moreno, Y Peng, YT Tang   +65 more
core   +7 more sources

TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

Journal of Pathology, 2021
Many chronic diseases are marked by fibrosis, which is defined by an abundance of activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of normal function of the affected organs.
Erine H. Budi, J. Schaub, M. Decaris, S. Turner, R. Derynck   +4 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Rat testicular germ cells and sertoli cells release different types of bioactive transforming growth factor beta in vitro

Reproductive Biology and Endocrinology, 2003
Several in vivo studies have reported the presence of immunoreactive transforming growth factor-β's (TGF-β's) in testicular cells at defined stages of their differentiation.
Themmen Axel PN, Hoogerbrugge Jos W, Haagmans Bart L, Teerds Katja J   +3 more
doaj   +1 more source

Crosstalk between Shh and TGF-β signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. [PDF]

PLoS ONE, 2013
BACKGROUND: Immunosuppressant cyclosporine-A induces gingival hyperplasia, which is characterized by increased fibroblast proliferation and overproduction of extracellular matrix components and regulated by transforming growth factor-beta (TGF-β).
Yi Chung, Earl Fu
doaj   +1 more source

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer [PDF]

, 2018
Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote
Carton, J, Gorroño-Etxebarria, I, Kypta, RM, Murillo-Garzón, V, Nees, M, Puustinen, MC, Sistonen, L, Waxman, J, Åkerfelt, M   +8 more
core   +3 more sources

TGF-β signaling in health, disease and therapeutics

Signal Transduction and Targeted Therapy
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular responses and is particularly critical to embryonic development, wound ...
Ziqin Deng, Tao Fan, Chu Xiao, He Tian, Yujia Zheng, Chunxiang Li, Jie He   +6 more
semanticscholar   +1 more source

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

Journal of Hematology & Oncology, 2021
Background Therapeutic antibodies targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis induce potent and durable anti-tumor responses in multiple types of cancers.
Ming Yi, Jing Zhang, Anping Li, Mengke Niu, Yongxiang Yan, Ying Jiao, S. Luo, P. Zhou, Kongming Wu   +8 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]

, 2017
While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse, Fisher, Amanda J., Gu, Hongmei, Mickler, Elizabeth A., Varre, Ananya, Vittal, Ragini   +5 more
core   +2 more sources