Results 71 to 80 of about 320,405 (317)

IL-10 and TGF-β1 evaluation in 3D human adipose-derived mesenchymal stem cells culture and hypoxic condition

Bioscience Journal, 2018
Mesenchymal stem cells (MSC) are multipotent cells derived from layer mesoderm and that have potential for self-renewal and cellular differentiation. These cells can be extracted from various tissues, being the main sources the bone marrow (BM) and adipose tissue (AT).
Vivian Alonso Goulart, Bárbara Cândido de Oliveira, Yasmin Twanne de Cássia Silva, Jéssica Regina Costa Silva, Cristiane Angélico Duarte, Isabela Lemos de Lima   +5 more
openaire   +4 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells. [PDF]

PLoS ONE, 2012
Apoptosis in ovarian surface epithelial (OSE) cells is induced by transforming growth factor-beta (TGF-β). However, high-grade serous ovarian carcinomas (HGC) are refractory to the inhibitory functions of TGF-β; their invasiveness is up-regulated by TGF ...
Jung-Chien Cheng, Nelly Auersperg, Peter C K Leung   +2 more
doaj   +1 more source

UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation and Does Not Affect Tumor-response to Irradiation

American Journal of Biomedical Sciences, 2014
UTL-5g is a small-molecule TNF- inhibitor having chemoprotective and liver radioprotective effects. We investigated the effects of UTL-5g on lung irradiated mice and whether UTL-5g affects tumor responses to radiotherapy. C57BL/6 mice were individually treated with UTL-5g at 15, 30, and 60 mg/kg and amifostine (200 mg/kg) by i.p.
Stephen Brown, Frederick Valeriote, Ben Chen, Kevin Bobbitt, Joseph Media, Halina Pietraszkiewicz, Jiajiu Shaw   +6 more
openaire   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Novel therapies emerging in oncology to target the TGF-β pathway

Journal of Hematology & Oncology, 2021
The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter or
Byung-Gyu Kim, Ehsan Malek, Sung Hee Choi, James J. Ignatz-Hoover, James J. Driscoll   +4 more
doaj   +1 more source

MOESM1 of CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

, 2018
Additional file 1: Table S1. Relationships between FoxP3+ and CD8+ infiltrating T cells and clinicopathological characteristics.
Pu, Ning, Zhao, Guochao, Yin, Hanlin, Li, Jian-ang, Nuerxiati, Abulimiti, Wang, Dansong, Xu, Xuefeng, Kuang, Tiantao, Jin, Dayong, Lou, Wenhui, Wu, Wenchuan   +10 more
openaire   +1 more source

KADAR TGF-β1 PLASMA DAN LIMFOSIT-T CD4+DI PENDERITA YANG TERINFEKSI HIV STADIUM I

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2018
HIV infection and AIDS have been spread throughout the world and the number of patients continues to increase from year to year.Indonesia is one of the countries with quite a high increase in the incidence of HIV and AIDS. The absolute number of CD4+T-lymphocytesand percentage in HIV-infected patients can be used to determine the stage of the disease ...
Albertina, Retnowati, Endang, Astha, Erwin   +2 more
openaire   +2 more sources

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay

BMC Research Notes, 2012
Background Transforming growth factor-β (TGF-β) is a multi-factorial peptide growth factor that has a vital role in the regulation of cell growth, differentiation, inflammation, and tissue repair.
Khan Shaukat A, Joyce Jennifer, Tsuda Takeshi   +2 more
doaj   +1 more source