Results 81 to 90 of about 2,112,620 (360)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression. [PDF]

PLoS ONE, 2012
The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor ...
Sun O Park, Mukesh Kumar, Sanjeev Gupta
doaj   +1 more source

The dynamic roles of TGF-β signalling in EBV-associated cancers [PDF]

, 2018
The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease.
Arvanitakis, Assoian, Cayrol, Chan, Christopher Dawson, Dalal, Derynck, Friedman, Gorsch, Gu, Ian Paterson, Kadin, Kumar, Lawrence Young, Lee Yap, Lo, MacDonald, Maeda, Moustakas, Newcom, Poh, Raftery, Segarini, Sekelsky, Sharmila Velapasamy, Yanagihara, Yap, Zhang   +27 more
core   +2 more sources

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family.

Developmental Cell, 2021
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics to migrate to other locations and acquire new properties. Epithelial plasticity responses are directed through cooperation of signaling pathways, with TGF-β and
Yoko Katsuno, R. Derynck
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

PRRX1 silencing is required for metastatic outgrowth in melanoma and is an independent prognostic of reduced survival in patients

Molecular Oncology
Paired related homeobox 1 (PRRX1) is an inducer of epithelial‐to‐mesenchymal transition (EMT) in different types of cancer cells. We detected low PRRX1 expression in nevus but increased levels in primary human melanoma and cell lines carrying the ...
Josep R. Ferreres, Antònia Vinyals, Rafael Campos‐Martin, Roderic Espín, Sebastian Podlipnik, Raquel Ramos, Esther Bertran, Cristina Carrera, Joaquim Marcoval, Josep Malvehy, Isabel Fabregat, Susana Puig, Àngels Fabra   +12 more
doaj   +1 more source

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

Cellular Physiology and Biochemistry, 2015
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse ...
Yinan Shen, Yongpeng Wei, Zhouchong Wang, Yingying Jing, Haiguan He, Jianyong Yuan, Rong Li, Qiudong Zhao, Lixin Wei, Tian Yang, Junhua Lu   +10 more
doaj   +1 more source

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition [PDF]

, 2018
The best characterized signaling pathway downstream of transforming growth factor β (TGF-β) is through SMAD2 and SMAD3. However, TGF-β also induces phosphorylation of SMAD1 and SMAD5, but the mechanism of this phosphorylation and its functional relevance
Anido, BabuRajendran, Bellomo, Campbell, Chen, Coda, Cuny, DaCosta Byfield, Daly, Daly, Diepenbruck, Dobin, Dontu, Gaarenstroom, Germain, Goumans, Goumans, Grönroos, Grünert, Hatsell, Heinz, Hino, Hoodless, Horton, Huang, Inman, Itoh, Kang, Kowanetz, Kretzschmar, Lasorella, Lechleider, Levy, Li, Li, Liu, Liu, Love, Luo, Massagué, Massagué, Massagué, Meulmeester, Michel, Miettinen, Miller, Minn, Miyazono, Morikawa, Morikawa, Nam, Nicolás, Nicolás, Padua, Padua, Pardali, Peinado, Piek, Qin, R Development Core Team, Ran, Robinson, Ross, Sako, Shi, Stankic, Subramanian, Takahashi, Vizán, Wakefield, Wang, Wieser, Wrana, Wrighton, Wu, Wu, Ye, Zhang   +77 more
core   +5 more sources

MOESM1 of Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

, 2019
Additional file 1. Supplemental information including figures.
Congcong Lu, Sidoli, Simone, Kulej, Katarzyna, Ross, Karen, Wu, Cathy, Garcia, Benjamin   +5 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source