Results 101 to 110 of about 2,112,620 (360)

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

Cell Research
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis ...
Mengrui Wu, Shali Wu, Wei Chen, Yi-Ping Li   +3 more
semanticscholar   +1 more source

Additional file 1: of FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

, 2017
Figure S1. FUT8 knockdown impaired the EMT in NMuMG cells. (PDF 102 kb)
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Kannagi, Reiji, Ruey-Bing Yang   +4 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing

Scientific Reports
Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling.
M. Alcaraz, I. Hernández-Mármol, J. M. Puente-Cuadrado, M. Rodríguez-Valiente, A. R. Silini, O. Parolini, F. J. Nicolás   +6 more
doaj   +1 more source

NAC and DTT promote TGF-β1 monomer formation: demonstration of competitive binding

Journal of Inflammation, 2006
TGF-β plays an important role in the genesis and progression of pulmonary fibrosis. We sought to determine the role of mononuclear phagocytes in the activation of TGF-β and found that freshly isolated peripheral blood monocytes spontaneously released TGF-
Frambach Gwyn, Hunter Melissa, Montague Christine R, Lichtenberger Frank J, Marsh Clay B   +4 more
doaj   +1 more source

Transforming Growth Factor-β Induces Transcription Factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene [PDF]

, 2013
Transforming growth factor-β (TGF-β) has multiple functions in embryogenesis, adult homeostasis, tissue repair, and development of cancer. Here, we report that TGF-β suppresses the transcriptional activation of the heme oxygenase-1 (HO-1) gene, which is ...
Igarashi Kazuhiko, Itoh Ken, Kamoshida Atsushi, Kato Mitsuyasu, Koinuma Daizo, Motohashi Hozumi, Ogami Tomohiro, Okita Yukari, Suzuki Hiroyuki, Yamamoto Masayuki, 加藤 光保, 鈴木 裕之   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts

Signal Transduction and Targeted Therapy
Transforming growth factor beta (TGF-β) signalling has become an attractive therapeutic target due to its pro-tumorigenic actions on epithelial cells and its immunosuppressive effects in the tumour microenvironment.
Josep Amengual, Ester Gonzalez-Sanchez, Mariana Yáñez-Bartolome, Laura Sererols-Viñas, Aashreya Ravichandra, Celia Guiton, Noel P. Fuste, Ania Alay, Sara Hijazo-Pechero, Beatriz Martín-Mur, Marta Gut, Anna Esteve-Codina, Ana Cantos-Cortes, Rut Espinosa-Sotelo, Emilio Ramos, Teresa Serrano, Mariona Calvo, Berta Laquente, Joana Ferrer, Gabriel Pons, Andrés Mendez-Lucas, Steven Dooley, Sumera I. Ilyas, Marie Vallette, Lynda Aoudjehane, Marie Lequoy, Laura Fouassier, Cédric Coulouarn, Silvia Affò, Alexander Scheiter, Diego F. Calvisi, Tian V. Tian, Isabel Fabregat, Javier Vaquero   +33 more
doaj   +1 more source

Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation.
Tao Zhang, Xiao-Feng Wang, Zheng-Cai Wang, Dong Lou, Qing-Qing Fang, Yan-Yan Hu, Wan-Yi Zhao, Li-yun Zhang, Li-Hong Wu, Wei-Qiang Tan   +9 more
semanticscholar   +1 more source

Additional file 1: of LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer

, 2019
Table S1. Oligonucleotides used for RT-qPCR, plasmid construction, RNA pull-down, siRNA, and GapmeR. (DOCX 25 kb)
Luo, Kaili, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Huang, Zheng, Shi, Ke-Qing, Chenwei Pan, Jianmin Wu   +8 more
openaire   +1 more source