Results 101 to 110 of about 320,405 (317)

TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

Molecular Oncology, 2018
Transforming growth factor‐beta (TGF‐β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF‐β on cancer development is
Yuanyuan Zhao, Jing Ma, Yanling Fan, Zhiyong Wang, Ran Tian, Wei Ji, Fei Zhang, Ruifang Niu   +7 more
doaj   +1 more source

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1Research in context

EBioMedicine, 2019
Background: Hyper-activation of TGF-β signaling is critically involved in progression of hepatocellular carcinoma (HCC). However, the events that contribute to the dysregulation of TGF-β pathway in HCC, especially at the post-translational level, are not
Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu   +10 more
doaj   +1 more source

Additional file 1: of miR-190 suppresses breast cancer metastasis by regulation of TGF-β-induced epithelialâ mesenchymal transition

, 2018
Supplementary Materials and Methods. Figure S1. miR-190 does not affect cell proliferation in breast cancer. Figure S2. miR-190 promotes cell invasion but does not affect cell proliferation in MDA-MB-231-luc cells. Figure S3. miR-190 suppresses breast cancer metastasis and EMT phenotype in BT549 cells. Table S1. Primers used for RT-qPCR. (DOCX 2080 kb)
Yu, Yue, Luo, Wei, Yang, Zheng-Jun, Chi, Jiang-Rui, Li, Yun-Rui, Ding, Yu, Ge, Jie, Wang, Xin, Cao, Xu-Chen   +8 more
openaire   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Additional file 2: Table S1. of Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition

, 2017
Sequences of the primers used in quantitative PCR analysis. (PDF 213Â kb)
Sommerova, Lucia, Ondrouskova, Eva, Vojtesek, Borivoj, Hrstka, Roman   +3 more
openaire   +1 more source

TGF-β/Smad signaling in renal fibrosis

Frontiers in Physiology, 2015
TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, Smad signaling is recognized as a major pathway of TGF-β signaling in progressive renal fibrosis. During fibrogenesis, Smad3 is highly activated, which is
Meng, Xiao-Ming, Tang, Patrick Ming-Kuen, Li, Jun, Lan, Hui Yao   +3 more
openaire   +3 more sources

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

A novel ALG10/TGF-β positive regulatory loop contributes to the stemness of colorectal cancer [PDF]

, 2022
Xiaotian Xu, Huideng Wang, Xinhui Li, Xiaoqun Duan, Yuhui Wang   +4 more
openalex   +1 more source

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source