Results 121 to 130 of about 13,045 (219)

Additional file 2: of The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

, 2019
Table S1. Correlation between LEF1 expression and clinicopathological characteristics in 243 patients. Table S2. Correlation between LEF1 expression and clinicopathological characteristics in total 338 patients. (DOCX 21 kb)
Zhao, Yue, Zhu, Ji, Shi, Bowen, Wang, Xinyu, Lu, Qijue, Li, Chunguang, Chen, Hezhong   +6 more
openaire   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Additional file 1: of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
Supplementary Notes. (PDF 107 kb)
Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan, White, Jacob, Yu, Hanry, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Additional file 1: of Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

, 2016
Presents the supplementary methods. (DOC 54 kb)
Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Zhang, Lei, Zhang, Chao, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Liang, Wei   +9 more
openaire   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Unraveling the influence of TGF-β rs9282871 and miRNA let-7c relative expression on TGF-β production in hepatocellular carcinoma patients

Journal of Genetic Engineering and Biotechnology
Hepatocellular carcinoma (HCC) is ranked globally as the second most common cancer-related death. Transforming growth factor beta (TGF-β) plays a dual role in HCC.
Sally Farouk, Maha M. Elbrashy, Ahmed Khairy, Noha G. Bader El Din   +3 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker

Frontiers in Oncology
BackgroundAstrocytic tumors, particularly glioblastomas, are aggressive brain malignancies with poor prognosis. Transforming growth factor-beta (TGF-β) isoforms—TGF-β-1, TGF-β-2, and TGF-β-3—play critical roles in glioma progression, yet their isoform ...
Klaudia Skóra, Klaudia Skóra, Damian Strojny, Damian Strojny, Damian Strojny, Dawid Sobański, Dawid Sobański, Rafał Staszkiewicz, Rafał Staszkiewicz, Rafał Staszkiewicz, Kamil Bryś, Paweł Gogol, Paweł Gogol, Paweł Gogol, Paweł Gogol, Krzysztof Bereza, Krzysztof Bereza, Michalina Masternak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek   +19 more
doaj   +1 more source

Additional file 3: Table S2. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
Parameters settings for different models. (PDF 47 kb)
Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan, White, Jacob, Yu, Hanry, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source