Results 141 to 150 of about 320,405 (317)

Abstract 843: CLDN1 mediates tumor invasion in HNSCC by regulation of EMT through AMPK-TGF-β signalling

, 2017
Jae Won Chang, Seung‐Nam Jung, Lihua Liua, Jin‐Man Kim, Myung Jin Ban, Yeon Kim, Bok‐Soon Lee, Yang Eun Kim, Ho Ryun Won, Chul‐Ho Kim, Bon Seok Koo   +10 more
openalex   +1 more source

The Role of TGF-β and Its Receptors in Gastrointestinal Cancers [PDF]

, 2018
Jingwen Luo, Xu‐Qiao Chen, Ping Li
openalex   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Additional file 3: Table S2. of Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

, 2017
Parameters settings for different models. (PDF 47 kb)
Li, Huipeng, Venkatraman, Lakshmi, Narmada, Balakrishnan, White, Jacob, Yu, Hanry, Tucker-Kellogg, Lisa   +5 more
openaire   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor

Cell Communication and Signaling
Background SRC homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), acting as a central node of many signaling pathways, has an emerging role in many diseases, including cancer.
Cen Zhao, Ihor Yakymovych, Mariya Yakymovych, Pengwei Xing, Carl-Henrik Heldin   +4 more
doaj   +1 more source

FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-β/β-catenin pathway [PDF]

, 2019
Shuangqing Li, Chao Tu, Lu Wan, Ruiqi Chen, Zhixi Duan, Xiaolei Ren, Zhihong Li   +6 more
openalex   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Additional file 1: of Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β

, 2019
Supplementary tables, methods, and figures (DOCX 1729 kb)
Goulart, Ernesto, Caires-Junior, Luiz, Telles-Silva, Kayque, Araujo, Bruno, Kobayashi, Gerson, Musso, Camila, Assoni, Amanda, Oliveira, Danyllo, Caldini, Elia, Gerstenhaber, Jonathan, Raia, Silvano, Lelkes, Peter, Zatz, Mayana   +12 more
openaire   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source