Results 1 to 10 of about 335,996 (268)

Growth factors as transforming proteins [PDF]

European Journal of Biochemistry, 1989
The growth of cells in culture is controlled by stimulatory or inhibitory factors. More than 20 different polypeptide growth factors have been structurally and functionally characterized, including cloning of their cDNAs (Table 1). The total number of polypeptide growth, factors is likely to be considerably higher, since additional factors, that have ...
C H, Heldin, B, Westermark
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Transforming growth factor-β in tumour development

Frontiers in Molecular Biosciences, 2022
Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function ...
Charles B. Trelford, Lina Dagnino, Lina Dagnino, Gianni M. Di Guglielmo   +3 more
doaj   +1 more source

TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

BMC Musculoskeletal Disorders, 2021
Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans.
Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso   +9 more
doaj   +1 more source

The Research Progress in Transforming Growth Factor-β2

Cells, 2023
Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation.
Meng-Yan Wang, Wen-Juan Liu, Le-Yi Wu, Gang Wang, Cheng-Lin Zhang, Jie Liu   +5 more
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Transforming Growth Factor-β1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. [PDF]

PLoS ONE, 2016
Familial sick sinus syndrome is associated with gene mutations and dysfunction of ion channels. In contrast, degenerative fibrosis of the sinus node tissue plays an important role in the pathogenesis of acquired sick sinus syndrome.
Jan-Yow Chen, Jiung-Hsiun Liu, Hong-Dar Isaac Wu, Kuo-Hung Lin, Kuan-Cheng Chang, Ying-Ming Liou   +5 more
doaj   +1 more source

Transforming Growth Factor-β1 to the Bone [PDF]

Endocrine Reviews, 2005
TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-β1 plays a major role in development and maintenance, affecting both
Janssens, Katrien, ten Dijke, Peter, Janssens, Sophie, Van Hul, Wim   +3 more
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Bone remodeling at microscrew interface near extraction site in the beagle dog mandible-histologic and immunohistochemical analyses

Journal of Applied Oral Science, 2013
Extraction is often used as part of orthodontic therapy, and good control of anchorage is a key step after extraction. Although microscrews can be implanted close to the extraction site in order to achieve orthodontic support, the efficiency of bone ...
Guangxi Wei, Yun Hu, Leilei Zheng, Jinfeng Huo, Tian Tang, Feng Deng   +5 more
doaj   +1 more source

Transforming growth factor-β1 and TGF-β2 act synergistically in the fibrotic pathway in oral submucous fibrosis: An immunohistochemical observation

Indian Journal of Medical and Paediatric Oncology, 2015
Background and objectives: Oral Submucous Fibrosis (OSF) is a potentially malignant oral disorder which leads to fibrosis of the oral mucosa and has a high rate of malignant transformation.
Venkatesh Viswanath Kamath, Shruti Krishnamurthy, Krishnanand P Satelur, Komali Rajkumar   +3 more
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Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

BMC Musculoskeletal Disorders, 2019
Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients.
Shotaro Takano, Kentaro Uchida, Makoto Itakura, Dai Iwase, Jun Aikawa, Gen Inoue, Manabu Mukai, Masayuki Miyagi, Kosuke Murata, Hiroyuki Sekiguchi, Masashi Takaso   +10 more
doaj   +1 more source