Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets [PDF]
MedCommCancer progression is often driven by aberrant cell growth and genetic mutations, leading to metastasis. The transforming growth factor‐beta (TGF‐β) pathway, a key regulator of cellular growth and differentiation, exhibits dual roles in cancer by ...
Reham Hassan Mekky +9 more
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Cell type–dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migration [PDF]
Neural Regeneration ResearchAdult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents. While it is known transforming growth factor-β signaling is important in embryonic neurogenesis, its role in postnatal neurogenesis remains unclear ...
Kierra Ware +3 more
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Role of transforming growth factor-β in peripheral nerve regeneration [PDF]
Neural Regeneration ResearchInjuries caused by trauma and neurodegenerative diseases can damage the peripheral nervous system and cause functional deficits. Unlike in the central nervous system, damaged axons in peripheral nerves can be induced to regenerate in response to ...
Zihan Ding +6 more
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β-Sitosterol Inhibits The Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway [PDF]
Cell Journal, 2023 Objective: To investigate the effect of β-sitosterol on endometrial cells to understand the underlying mechanism.Materials and Methods: This is a laboratory-based experimental study conducted on animals and cells.
Yi Wen +6 more
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Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation
Frontiers in Cell and Developmental Biology, 2021 Appropriate growth and development of the endometrium across the menstrual cycle is key for a woman’s quality of life and reproductive well-being. Recurrent pregnancy loss (RPL) and heavy menstrual bleeding (HMB) affect a significant proportion of the ...
Qinsheng Lu +7 more
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Transforming growth factor-β in tumour development
Frontiers in Molecular Biosciences, 2022 Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function ...
Charles B. Trelford +3 more
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Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer
Frontiers in Cell and Developmental Biology, 2022 Complexity in mechanisms that drive cancer development and progression is exemplified by the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage hyperplasia, yet assists aggressive tumors to achieve metastasis.
Dorival Mendes Rodrigues-Junior +4 more
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Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
Open Biology, 2021 Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this ...
Xinyi Wang +4 more
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THU0271 SERUM LEVELS OF TRANSFORMING GROWTH FACTOR î‘ (TGF-î‘) IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME [PDF]
Annals of the Rheumatic Diseases, 2019 Background Primary Sjogren’s syndrome (pSS) is an autoimmune disease affecting primarily exocrine, especially salivary, glands. The epithelial damage, autoantigens release, activation of innate and acquired immunity form the underlaying of the pSS pathogenesis. The main role in pSS is played by B-lymphocytes and production of autoantibodies.
Maria Maślińska +4 more
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Correlation of Expression Transforming Growth Factor-β1, E-cadherin, and Ki-67 in Meningiomas
Open Access Macedonian Journal of Medical Sciences, 2020 BACKGROUND: Meningioma is the most common primary intracranial tumors in adults, accounts for 36% of total intracranial tumors. Obtaining the clinicopathological characteristics of patients with meningioma and investigating, the association between signaling pathways with disease progression could provide a basis for therapeutic development.AIM: This ...
Apriyanto Apriyanto +3 more
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