TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model
BMC Musculoskeletal Disorders, 2021 Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans.
Yuji Yokozeki +9 more
doaj +1 more source
Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer. [PDF]
PLoS ONE, 2014 Lung cancer is the second most common cancer and the leading cause of cancer-related deaths. Despite recent advances in the development of targeted therapies, patients with advanced disease remain incurable, mostly because metastatic non-small cell lung ...
Edna Gordian +8 more
doaj +1 more source
Regulation of the transforming growth factor β pathway by reversible ubiquitylation [PDF]
Open Biology, 2012 The transforming growth factor β (TGFβ) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD ...
Mazin A. Al-Salihi +2 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2018 Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying skeletal muscle fibrosis remains unveiled.
Yaying Sun +5 more
doaj +1 more source
Expression of epidermal growth factor and transforming growth factor α in interfacial membranes retrieved at revision total hip arthroplasty [PDF]
Annals of the Rheumatic Diseases, 2000 The interfacial membrane between bone and implant has been shown to be a key tissue in the process of aseptic loosening of total hip arthroplasty. The cells within the interfacial membrane produce numerous inflammatory mediators which, through complex mechanisms, cause periprosthetic osteolysis and aseptic loosening.
J W, Xu +6 more
openaire +2 more sources
Transforming growth factor-β in diabetic nephropathy
The Egyptian Journal of Internal Medicine, 2013 Background Renal failure is a common and serious complication of long-standing diabetes mellitus. Diabetes is the most common cause of end-stage renal failure.
Karima Y. Ahmed +3 more
doaj +1 more source
BMC Cell Biology, 2009 Background β-catenin and transforming growth factor β signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth ...
Slade Laura +4 more
doaj +1 more source
Kadar Kortisol, Transforming Growth Factor β, serta Derajat Adhesi Pasca Laparoskopi dan Laparotomi
Jurnal Kedokteran Brawijaya, 2016 Adhesi intraperitoneal pasca bedah abdomen terjadi pada 50-97% kasus adhesi, dengan penyebab terbanyak adalah laparotomi. Penelitian ini bertujuan membuktikan perbedaan dampak laparoskopi dan laparotomi terhadap derajat adhesi peritoneal, kadar kortisol dan TGF-β.
Agung Pribadi +2 more
openaire +1 more source
Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium
BMC Musculoskeletal Disorders, 2019 Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients.
Shotaro Takano +10 more
doaj +1 more source
Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. [PDF]
PLoS ONE, 2014 The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium.
Rune B Jakobsen +4 more
doaj +1 more source