Results 1 to 10 of about 166,768 (353)

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases

Cells, 2021
TGF-β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-β/Smad signalling pathway have been found to produce disparate effects on neurogenesis.
Chi-Him Poon, Lee-Wei Lim
exaly   +3 more sources

Systems theory of Smad signaling [PDF]

IEE Proceedings - Systems Biology, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the ...
Alves, Alves, Barkai, Battogtokh, Brightman, Brown, Brown, Chacko, Chen, Colland, Conery, D.C. Clarke, Derynck, Dong, Fink, Funaba, Fung, Gardner, Hager, Haugh, Hoffmann, Huang, Inman, Inman, Jayaraman, Kawabata, Kholodenko, Kim, Lagna, Lander, Lee, Liu, M.D. Betterton, Massague, Massague, Massague, Nakao, Nakao, Nicolas, Nicolas, Park, Pasche, Pierreux, Poncelet, Remy, Schmierer, Schoeberl, Sedaghat, Shi, Shi, Subramanian, ten Dijke, Tewari, Tian, Tsukazaki, Vilar, von Dassow, Wu, X. Liu, Xu, Xu, Yamada, Zhang, Zi   +63 more
core   +3 more sources

Phosphatases in SMAD regulation [PDF]

FEBS Letters, 2012
SMAD transcription factors are key mediators of the transforming growth factor‐beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by
Gopal P Sapkota
exaly   +4 more sources

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

Diagnostics, 2023
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway.
Fei Xiong
exaly   +3 more sources

The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia

Tumor Biology, 2017
The SMAD proteins are responsible for transducing signals from activated transforming growth factor-beta. This is the first study assessing the expression of SMAD-1/8, SMAD-2/3, SMAD-4, and SMAD-7 in chronic lymphocytic leukemia cells with regard to ...
Magdalena Witkowska, Agata Majchrzak, Barbara Cebula-Obrzut   +2 more
exaly   +2 more sources

Genetic Algorithm-Based Method for Discovering Involutory MDS Matrices

Computational and Mathematical Methods, 2023
In this paper, we present an innovative approach for the discovery of involutory maximum distance separable (MDS) matrices over finite fields F2q, derived from MDS self-dual codes, by employing a technique based on genetic algorithms. The significance of
El Mehdi Bellfkih, Said Nouh, Imrane Chems Eddine Idrissi, Khalid Louartiti, Jamal Mouline   +4 more
doaj   +1 more source

It’s a SMAD/SMAD World [PDF]

Cell, 2015
DPC4/SMAD4 mutations are associated with aggressive pancreatic cancer. In this issue of Cell, Whittle et al. demonstrate that Runx3 expression combined with Dpc4/Smad4 status can predict the metastatic propensity of pancreatic tumors, providing valuable guidance for personalized therapy for patients with pancreatic cancer.
Taniguchi, Cullen, Maitra, Anirban
openaire   +2 more sources

Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm

Frontiers in Aging Neuroscience, 2021
Background: CircRNAs have been found to play a crucial role in the pathological process of various kinds of diseases. However, the role of circRNAs in the formation and rupture of intracranial aneurysm is still unknown.Methods: Differentially expressed ...
Xin Chen, Xin Chen, Xin Chen, Xin Chen, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Shuzhe Yang, Junhua Yang, Junhua Yang, Junhua Yang, Junhua Yang, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Qingyuan Liu, Maogui Li, Maogui Li, Maogui Li, Maogui Li, Jun Wu, Jun Wu, Jun Wu, Jun Wu, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Shuo Wang, Shuo Wang, Shuo Wang, Shuo Wang   +31 more
doaj   +1 more source

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]

Open Biology, 2014
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Lina Herhaus, Mazin A. Al-Salihi, Kevin S. Dingwell, Timothy D. Cummins, Lize Wasmus, Janis Vogt, Richard Ewan, David Bruce, Thomas Macartney, Simone Weidlich, James C. Smith, Gopal P. Sapkota   +11 more
doaj   +1 more source

Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells

Frontiers in Immunology, 2021
The mechanisms of diabetic retinopathy (DR), are not yet fully understood. We previously demonstrated an upregulation of retinal bone morphogenetic protein-2 (BMP2) in experimental diabetes and in retinas of diabetic human subjects.
Mohamed Al-Shabrawey, Mohamed Al-Shabrawey, Mohamed Al-Shabrawey, Mohamed Al-Shabrawey, Khaled Hussein, Khaled Hussein, Fang Wang, Fang Wang, Ming Wan, Ming Wan, Khaled Elmasry, Khaled Elmasry, Nehal Elsherbiny, Nehal Elsherbiny, Heba Saleh, Paul B. Yu, Amany Tawfik, Amany Tawfik, Amany Tawfik, Ahmed S. Ibrahim, Ahmed S. Ibrahim   +20 more
doaj   +1 more source