Results 11 to 20 of about 166,768 (353)
The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1 [PDF]
Open Biology, 2013 The signalling pathways downstream of the transforming growth factor beta (TGFβ) family of cytokines play critical roles in all aspects of cellular homeostasis.
Gopal P. Sapkota
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The Journal of Poultry Science, 2022 Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu +5 more
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The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats
Open Life Sciences, 2021 The areca nut is one of the most commonly consumed psychoactive substances worldwide, with an estimated consumption by approximately 10% of the world’s population, especially in some regions of South Asia, East Africa, and the tropical Pacific. Arecoline,
Ku Chang-Wen +7 more
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Advances on TGF-β/Smad signal pathway in hepatic fibrosis
生物医学转化, 2021 The transforming growth factor-β (TGF-β) signaling pathway plays a vital role in regulating cell processes. As far as the liver is concerned, the TGF-β signaling pathway runs through liver diseases, from theinitial liver cell injury to inflammation ...
Han Daoning, Su Xiulan
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All Life, 2022 Osteosarcoma (OS), a common bone malignancy, is highly metastatic and featured by poor prognosis. SUMOylation is deeply involved in tumorigenesis and cancer progression.
Xiangang Jin +5 more
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Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats
Frontiers in Pharmacology, 2018 Background: Liver fibrosis is a complex inflammatory and fibrogenic process, and the progression of fibrosis leads to cirrhosis. The only therapeutic approaches are the removal of injurious stimuli and liver transplantation. Therefore, the development of
Masatsugu Ohara +7 more
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Biomolecules, 2020 Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological embryogenesis and adult tissue homeostasis.
Kalliopi Tzavlaki, Aristidis Moustakas
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The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers
Biomolecules, 2023 Transforming growth factor-β (TGF-β) has attracted attention as a tumor suppressor because of its potent growth-suppressive effect on epithelial cells.
Tasuku Matsuoka, Masakazu Yashiro
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Microorganisms, 2021 Virus–host cell interactions in rubella virus (RuV) are of great interest in current research in the field, as their mechanism is not yet well understood.
Ngan Thi Kim Pham +8 more
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Turning off Smads: Identification of a Smad Phosphatase [PDF]
Developmental Cell, 2006 Although the activation of Smad signaling pathways downstream of TGF-beta superfamily ligands by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphatases that turn off Smad activity. Recently in Genes & Development, describe pyruvate dehydrogenase phosphatase as a Smad1 phosphatase that functions in Drosophila
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