Results 41 to 50 of about 104,390 (258)

Deep learning for de-convolution of Smad2 versus Smad3 binding sites

BMC Genomics, 2022
Background The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets ...
Jeremy W.K. Ng, Esther H.Q. Ong, Lisa Tucker-Kellogg, Greg Tucker-Kellogg   +3 more
doaj   +1 more source

Systems theory of Smad signalling [PDF]

IEE Proceedings - Systems Biology, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes.
Clarke, D. C., Betterton, M. D., Liu, X.
openaire   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Frontiers in Molecular Biosciences, 2021
Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts.
Ming-Li Zou, Ming-Li Zou, Zhong-Hua Chen, Ying-Ying Teng, Si-Yu Liu, Si-Yu Liu, Yuan Jia, Yuan Jia, Kai-Wen Zhang, Kai-Wen Zhang, Zi-Li Sun, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Yi Feng, Xia Li, Rui-Sheng Xu, Feng-Lai Yuan   +17 more
doaj   +1 more source

Regulation of Smad activities [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2006
TGF-beta (Transforming Growth Factor-beta) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-beta stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression.
openaire   +3 more sources

MdmX inhibits Smad transactivation [PDF]

Oncogene, 2002
Mdm2 overexpression confers a growth promoting activity upon cells primarily by downregulating the p53 tumor suppressor protein. Nevertheless, Mdm2 deregulation has also been implicated in inhibiting TGF-beta growth repression in a p53 independent manner.
Kadakia, Madhavi, Brown, Thomas L., McGorry, Molly M., Berberich, Steven J.   +3 more
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

IL1B induced Smad 7 negatively regulates gastrin expression. [PDF]

PLoS ONE, 2011
BACKGROUND: Helicobacter pylori elicited IL1B is one of the various modulators responsible for perturbation of acid secretion in gut. We have earlier reported that IL1B activated NFkB downregulates gastrin, a major modulator of acid secretion.
Dipanjana Datta De, Sumana Bhattacharjya, Meenakshi Maitra, Arindam Datta, Abhijit Choudhury, G K Dhali, Susanta Roychoudhury   +6 more
doaj   +1 more source

Identification of a Smad Phosphatase [PDF]

ACS Chemical Biology, 2006
Activation of Smad signaling pathways downstream of TGF-beta superfamily ligands via receptor-mediated Smad phosphorylation is well understood, but little is known about the phosphatases that turn off Smad activity. Now in Cell, Feng and colleagues (Lin, X., et al.
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source