Results 41 to 50 of about 166,768 (353)
CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling [PDF]
Journal of Biological Chemistry, 2001 In normal adult fibroblasts, transforming growth factor-beta (TGFbeta) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and matrix deposition, and in acute models of fibrosis promotes cell proliferation and collagen deposition acting synergistically with TGFbeta.
A, Holmes +5 more
openaire +2 more sources
Contextual Regulation of TGF-β Signaling in Liver Cancer
Cells, 2019 Primary liver cancer is one of the leading causes for cancer-related death worldwide. Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through membrane receptors and intracellular Smad proteins, which enter the nucleus ...
Shuo Tu +4 more
doaj +1 more source
A Folk Tale of a Butterfly [PDF]
, 2009 This folk tale describes how a butterfly and worm respect one anotherThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad Village
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Deep learning for de-convolution of Smad2 versus Smad3 binding sites
BMC Genomics, 2022 Background The transforming growth factor beta-1 (TGF β-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature suggests that TGF β-1 signaling outcome is partially dependent on the regulatory targets ...
Jeremy W.K. Ng +3 more
doaj +1 more source
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
Frontiers in Molecular Biosciences, 2021 Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts.
Ming-Li Zou +17 more
doaj +1 more source
A Folk Tale of a Poor Man [PDF]
, 2009 Bstan 'dzin tells a folk tale in which a poor man outsmarts a rich manThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad ...
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
IL1B induced Smad 7 negatively regulates gastrin expression. [PDF]
PLoS ONE, 2011 BACKGROUND: Helicobacter pylori elicited IL1B is one of the various modulators responsible for perturbation of acid secretion in gut. We have earlier reported that IL1B activated NFkB downregulates gastrin, a major modulator of acid secretion.
Dipanjana Datta De +6 more
doaj +1 more source
A Folk Tale of Uncle Ston pa [PDF]
, 2009 This folk tale relates the exploits of the Tibetan trickster uncle Ston paThis collection of 77 audio files focuses on weddings and weddings speeches but also contains: folk tales, folk songs, riddles, tongue twisters, and local history from Bang smad ...
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