Results 31 to 40 of about 104,390 (258)
Posttranslational Regulation of Smads [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of gene expression responses, which are extensively regulated at multiple levels and vary depending on the physiological context. The formation, activation, and destruction of two major functional complexes in the TGF-β signaling pathway (i.e., the TGF-β receptor ...
Pinglong, Xu, Xia, Lin, Xin-Hua, Feng
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A Smad Transcriptional Corepressor [PDF]
Cell, 1999 Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein and a repressor of transcription. A
Wotton, David +3 more
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Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. [PDF]
PLoS ONE, 2012 The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and proliferation.
Chris Hough, Maria Radu, Jules J E Doré
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Brazilian Neurosurgery, 2023 Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade ...
Güven Gürsoy +4 more
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules, 2019 The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego +4 more
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Non-coding RNA Research, 2021 One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of ...
Aima Adylova +4 more
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Smad transcription factors [PDF]
Genes & Development, 2005 Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Joan, Massagué +2 more
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Contextual Regulation of TGF-β Signaling in Liver Cancer
Cells, 2019 Primary liver cancer is one of the leading causes for cancer-related death worldwide. Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through membrane receptors and intracellular Smad proteins, which enter the nucleus ...
Shuo Tu +4 more
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CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling [PDF]
Journal of Biological Chemistry, 2001 In normal adult fibroblasts, transforming growth factor-beta (TGFbeta) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and matrix deposition, and in acute models of fibrosis promotes cell proliferation and collagen deposition acting synergistically with TGFbeta.
A, Holmes +5 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source