Results 31 to 40 of about 166,768 (353)
Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins [PDF]
Open Biology, 2012 Transforming growth factor β superfamily members signal through Smad transcription factors. Bone morphogenetic proteins (BMPs) act via Smads 1, 5 and 8 and TGF-βs signal through Smads 2 and 3.
Elizabeth M. Callery +5 more
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Posttranslational Regulation of Smads [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of gene expression responses, which are extensively regulated at multiple levels and vary depending on the physiological context. The formation, activation, and destruction of two major functional complexes in the TGF-β signaling pathway (i.e., the TGF-β receptor ...
Pinglong, Xu, Xia, Lin, Xin-Hua, Feng
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A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment
Biomolecules, 2019 Transforming growth factor (TGF)-β is a secreted multifunctional cytokine that signals via plasma membrane TGF-β type I and type II receptors and intercellular SMAD transcriptional effectors.
Linh Khanh Huynh +2 more
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Cells, 2020 Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-β1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (CD105)
Tania Aguado +7 more
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A Smad Transcriptional Corepressor [PDF]
Cell, 1999 Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein and a repressor of transcription. A
Wotton, David +3 more
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Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. [PDF]
PLoS ONE, 2012 The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and proliferation.
Chris Hough, Maria Radu, Jules J E Doré
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Brazilian Neurosurgery, 2023 Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade ...
Güven Gürsoy +4 more
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Non-coding RNA Research, 2021 One of the complex themes in recent years has been the multi-layered regulation of TGFβ signaling in cancer cells. TGFβ/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of ...
Aima Adylova +4 more
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules, 2019 The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego +4 more
doaj +1 more source
Smad transcription factors [PDF]
Genes & Development, 2005 Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Joan, Massagué +2 more
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