Results 1 to 10 of about 92,230 (263)

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity [PDF]

eLife
The endolysosomal phospholipid bis(monoacylglycerol)phosphate (BMP) is aberrantly elevated in urine from Parkinson’s patients carrying mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase). Because BMP resides on, and regulates
Elsa Meneses-Salas, Moises Castellá, Marianna Arnold, Frank Hsieh, Rubén Fernández-Santiago, Mario Ezquerra, Alicia Garrido, María-José Martí, Carlos Enrich, Suzanne R Pfeffer, Kalpana Merchant, Albert Lu   +11 more
doaj   +2 more sources

Full-length transcriptome and analysis of bmp-related genes in Platypharodon extremus

Heliyon, 2022
Platypharodon extremus is an endemic species on the Qinghai–Tibet Plateau. As a secondary protected species in China, the basic genomic information of this species has not yet been reported.
Xiaoyun Wu, Quan Gong, Yeyu Chen, Ya Liu, Mingjiang Song, Feiyang Li, Pengcheng Li, Jiansheng Lai   +7 more
doaj   +1 more source

Simulation-optimization framework in urban flood management for historic and climate change scenarios

Journal of Water and Climate Change, 2022
A simulation-optimization framework is established by integrating Hydrologic Engineering Center Hydraulic Modeling System (HEC-HMS) for computation of runoff, siting tool EPA System for Urban Storm-water Treatment and Analysis INtegration (EPA-SUSTAIN ...
R. Madhuri, Y. S. L. Sarath Raja, K. Srinivasa Raju   +2 more
doaj   +1 more source

Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

eLife, 2022
Production and emigration of neural crest cells is a transient process followed by the emergence of the definitive roof plate. The mechanisms regulating the end of neural crest ontogeny are poorly understood. Whereas early crest development is stimulated
Dina Rekler, Chaya Kalcheim
doaj   +1 more source

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism [PDF]

Open Biology, 2018
The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children.
Max D. Knickmeyer, Juan L. Mateo, Priska Eckert, Eleni Roussa, Belal Rahhal, Aimee Zuniga, Kerstin Krieglstein, Joachim Wittbrodt, Stephan Heermann   +8 more
doaj   +1 more source

Novel Indolyl-Benzimidazole Compounds Promote in vitro Wound Healing and Osteogenic Differentiation of Pluripotent Cells

Frontiers in Bioscience-Landmark, 2023
Background: Increasing or restoring Bone Morphogenetic Protein- (BMP-) signaling through administration of recombinant BMPs (rBMPs) has demonstrated therapeutic efficacy for treating bone fractures or to enhance repair following spinal surgeries. However,
Sheyda Najafi, Leonard Barasa, Jilian Maxine J. Frianela, Jawaher H. Alkhamisy, Sabesan Yoganathan, Jeanette C. Perron   +5 more
doaj   +1 more source

Quantitative analysis of signaling responses during mouse primordial germ cell specification

Biology Open, 2021
During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani, Anna-Katerina Hadjantonakis   +1 more
doaj   +1 more source

Anaerobic digestibility of aerobic granular sludge from continuous flow reactors: the role of granule size distribution

Water Science and Technology, 2023
There is an increasing interest in integrating aerobic granular sludge (AGS) technology into wastewater industries. Several projects are being performed to cultivate the aerobic granules for continuous flow reactors (AGS-CFR), while there is a scarcity ...
Salahaldeen Dababat, Stephan Berzio, Marc Wichern, Manfred Lübken   +3 more
doaj   +1 more source

Changes of BMP-2 and BMP-4 in early phase of sepsis [PDF]

Jichu yixue yu linchuang, 2022
Objective To study the change of serum bone morphogenetic protein (BMP)-2 and BMP-4 during the development of sepsis and its mechanisms. Methods Blood was collected for quantifying serum BMP-2 and BMP-4 from patients with sepsis (sepsis group), patients ...
WEN Yan, LIN Jin-can, HUANG Ying-hong, XIAO Wen-biao, ZHANG Min-wei, LIN Jian-dong
doaj   +1 more source

Embryonic Patterning: To BMP or Not to BMP, That Is the Question [PDF]

Cell, 1997
Although some progress in understanding the molecular mechanisms of early embryogenesis has been made, a few outstanding issues remain to be clarified. Of particular interest is whether dorsal–ventral patterning of the endoderm is also controlled by BMP signaling.
openaire   +2 more sources