Results 41 to 50 of about 148,190 (307)

The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence

American Journal of Otolaryngology, 2013
The aim of our study was to investigate the relationship between the destruction of temporal bone structures, ossicular chain destruction, dissemination of cholesteatoma and the expressions of bone morphogenetic proteins (BMPs), BMP-2, BMP-4 and BMP-6 in patients with acquired cholesteatoma.This study was performed in a total of 80 patients with ...
Öger, Muzaffer, Alpay, Hayrettin Cengiz, Orhan, İsrafil, Önalan Ethem, Ebru, Yanılmaz, Muhammed, Sapmaz, Emrah   +5 more
openaire   +3 more sources

The pro-BMP activity of Twisted gastrulation is independent of BMP binding [PDF]

Development, 2003
The determination of the vertebrate dorsoventral body axis is regulated in the extracellular space by a system of interacting secreted molecules consisting of BMP, Chordin, Tolloid and Twisted Gastrulation (Tsg). Tsg is a BMP-binding protein that forms ternary complexes with BMP and Chordin.
Michael, Oelgeschläger, Bruno, Reversade, Juan, Larraín, Shawn, Little, Mary C, Mullins, E M, De Robertis   +5 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

Bone Research, 2015
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases.
Md Shaifur Rahman, Naznin Akhtar, H. M. Jamil, R. Banik, S. M. Asaduzzaman   +4 more
semanticscholar   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal

Fly, 2017
Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration.
Aiguo Tian, Jin Jiang
doaj   +1 more source

Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans

Cell & Bioscience, 2022
Background Bone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in several age-related diseases including cancer, Alzheimer’s disease, obesity, and cardiovascular disease.
Mehul Vora, Arindam Mondal, Dongxuan Jia, Pranya Gaddipati, Moumen Akel, John Gilleran, Jacques Roberge, Christopher Rongo, John Langenfeld   +8 more
doaj   +1 more source

Transforming growth factor-β superfamily, implications in development and differentiation of stem cells

Biomolecular Concepts, 2012
Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells.
Santibanez Juan F., Kocic Jelena
doaj   +1 more source

BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors

Development, 2016
The pseudostratified epithelium of the lung contains ciliated and secretory luminal cells and basal stem/progenitor cells. To identify signals controlling basal cell behavior we screened factors that alter their self-renewal and differentiation in a ...
Tomomi Tadokoro, Xia Gao, C. Hong, Danielle F Hotten, B. Hogan   +4 more
semanticscholar   +1 more source