Results 61 to 70 of about 148,190 (307)
BMPs and their clinical potentials
BMB Reports, 2011 Bone morphogenetic protein (BMP) signaling in diseases is the subject of an overwhelming array of studies. BMPs are excellent targets for treatment of various clinical disorders. Several BMPs have already been shown to be clinically beneficial in the treatment of a variety of conditions, including BMP-2 and BMP-7 that have been approved for clinical ...
Meejung, Kim, Senyon, Choe
openaire +3 more sources
Advanced Science, EarlyView.In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor +11 more
wiley +1 more source
BMP signaling and its paradoxical effects in tumorigenesis and dissemination
OncoTarget, 2016 Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal development by regulating cell differentiation, proliferation, motility, and survival, thus maintaining homeostasis during organ and tissue development.
Li-Jie Zhang +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun +10 more
wiley +1 more source
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis
Advanced Science, EarlyView.A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa +5 more
wiley +1 more source
The formative evaluation of a forestry Best Management Practices program in a municipal watershed
The Forestry Chronicle, 2020 Best Management Practices for water quality (BMPs) have been proven effective in reducing sedimentation from timber harvesting operations. Although most states in the country have BMP guidelines, many are non-regulatory, creating challenges for forest ...
Emily Paye +2 more
doaj +1 more source
Signaling cross-talk between TGF-β/BMP and other pathways
Cell Research, 2009 Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in the vast majority of cellular processes and is fundamentally important during the entire life of all metazoans.
Xing Guo, Xiao-Fan Wang
semanticscholar +1 more source
Advanced Science, EarlyView.NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen +7 more
wiley +1 more source