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Advanced Functional Materials, 2023 The treatment of irregular bone defects remains a clinical challenge since the current biomaterials (e.g., calcium phosphate bone cement (CPC)) mainly act as inert substitutes, which are incapable of transforming into a regenerated host bone (termed ...
Jinzhong Zhao, Dai-Xu Wei
exaly +3 more sources
Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome?
Periodontology 2000, 2023 The key factors that are needed for bone regeneration to take place include cells (osteoprogenitor and immune-inflammatory cells), a scaffold (blood clot) that facilitates the deposition of the bone matrix, signaling molecules, blood supply, and ...
Elena Calciolari +2 more
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Lymphatic vessels in bone support regeneration after injury
Cell, 2023 Summary Blood and lymphatic vessels form a versatile transport network and provide inductive signals to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and hematopoiesis, but current dogma suggests that bone lacks ...
Anjali P Kusumbe
exaly +2 more sources
Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration
Nano-Micro LettersRecent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are summarized.
Jianshu Li, Kun Ling, Yongping Lu
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Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur
Bioengineering, 2023 The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca +8 more
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Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts
Journal of Functional Biomaterials, 2023 Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato +5 more
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Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis
Frontiers in Endocrinology, 2022 Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Weidong Zhang +13 more
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Advancement of science, 2023 The treatment of bone defects remains a substantial clinical challenge due to the lack of spatiotemporal management of the immune microenvironment, revascularization, and osteogenic differentiation.
Min-Hao Wu +9 more
semanticscholar +1 more source
Journal of Functional Biomaterials, 2022 Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano +2 more
doaj +1 more source
Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems
ACS Biomaterials Science & Engineering, 2023 Novel tissue regeneration strategies are constantly being developed worldwide. Research on bone regeneration is noteworthy, as many promising new approaches have been documented with novel strategies currently under investigation. Innovative biomaterials
Aleksandra Szwed-Georgiou +13 more
semanticscholar +1 more source