Results 1 to 10 of about 577,014 (316)
Prioritization and functional validation of target genes from single-cell transcriptomics studies
Communications Biology, 2023 Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional validation, it
Liliana Sokol +12 more
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Meta‐analysis of clinical metabolic profiling studies in cancer: challenges and opportunities
EMBO Molecular Medicine, 2016 Cancer cell metabolism has received increasing attention. Despite a boost in the application of clinical metabolic profiling (CMP) in cancer patients, a meta‐analysis has not been performed.
Jermaine Goveia +9 more
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Angiogenesis and angiogenesis inhibitors in paediatric diseases
European Journal of Pediatrics, 1992 Angiogenesis, the generation of new capillaries from existing blood vessels, is rarely observed in the healthy organism, but can present during various paediatric diseases. In this review, we describe recent progress in the understanding of pathological angiogenesis and approaches for an improved therapy of angiogenic childhood diseases.
Schweigerer, L., Fotsis, T.
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background The present study demonstrates that the ubiquitin E3 ligase, Pellino‐1 (Peli1), is an important angiogenic molecule under the control of vascular endothelial growth factor (VEGF) receptor 2/Flk‐1.
Mahesh Thirunavukkarasu +13 more
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Cell Death and Disease, 2021 Dental pulp stem cells (DPSC) are capable of differentiating into vascular endothelial cells. Although the capacity of vascular endothelial growth factor (VEGF) to induce endothelial differentiation of stem cells is well established, mechanisms that ...
Zhaocheng Zhang +3 more
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A transgenic Xenopus laevis reporter model to study lymphangiogenesis
Biology Open, 2013 Summary The importance of the blood- and lymph vessels in the transport of essential fluids, gases, macromolecules and cells in vertebrates warrants optimal insight into the regulatory mechanisms underlying their development.
Annelii Ny +13 more
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PHD2 regulates arteriogenic macrophages through TIE2 signalling
EMBO Molecular Medicine, 2013 Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype ...
Alexander Hamm +14 more
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Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
Nature Communications, 2022 The pro-tumorigenic effects of vimentin have been attributed to intracellular functions in tumour cells so far. Here, the authors show that tumour endothelial cells can secrete vimentin as a pro-angiogenic factor and that targeting of vimentin can be ...
Judy R. van Beijnum +11 more
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Molecular Cancer, 2018 Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes.
Ramesh Butti +5 more
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Angiogenesis in Glioblastoma [PDF]
New England Journal of Medicine, 2013 Recent work suggests that glioblastoma cells can differentiate into endothelial cells and pericytes, thus providing a means of tumor vascularization.
Sunit, Das, Philip A, Marsden
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