Results 21 to 30 of about 486,070 (267)
High mitogenic stimulation arrests angiogenesis
Nature Communications, 2019 High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high ...
Samuel Pontes-Quero +9 more
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Publisher Correction: High mitogenic stimulation arrests angiogenesis
Nature Communications, 2019 The original version of this Article contained errors in Fig. 8. In panel a, the labels ‘VEGF’, ‘Notch’, ‘p21’, and ‘P-ERK’ were inadvertently omitted. This has been corrected in the PDF and HTML versions of the Article.
Samuel Pontes-Quero +9 more
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How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors
Frontiers in Immunology, 2017 Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life, ECs can rapidly switch to a migratory “tip” cell and a ...
Annalisa Zecchin +7 more
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Glycolytic regulation of cell rearrangement in angiogenesis
Nature Communications, 2016 Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing ...
Bert Cruys +15 more
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Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis [PDF]
Journal of Vascular Research, 2012 Angiogenesis, i.e. the development and growth of blood vessels, is a major topic of research as it plays an important role in normal development and in various pathologies. Recent evidence revealed the existence of different mechanisms of blood vessel growth, including sprouting and intussusceptive angiogenesis, vascular mimicry, and blood vessel ...
De Spiegelaere, Ward +7 more
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Poststroke Angiogenesis, Con [PDF]
Stroke, 2015 Angiogenesis, the regrowth of new blood vessels, occurs after stroke1 and thus raises hopes that this regeneration is beneficial for patients with stroke. There is no doubt, that the restoration of blood supply, providing oxygen and nutrients to the ischemic brain tissue, is beneficial for stroke recovery.
J. Adamczak, M. Hoehn
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iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications
Nature Communications, 2019 The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre ...
Macarena Fernández-Chacón +6 more
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Angiogenesis in the lung [PDF]
The Journal of Physiology, 2018 AbstractBoth systemic (tracheal and bronchial) and pulmonary circulations perfuse the lung. However, documentation of angiogenesis of either is complicated by the presence of the other. Well‐documented angiogenesis of the systemic circulations have been identified in asthma, cystic fibrosis, chronic thromboembolism and primary carcinomas.
Lindsey Eldridge, Elizabeth M. Wagner
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Prioritization and functional validation of target genes from single-cell transcriptomics studies
Communications Biology, 2023 Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional validation, it
Liliana Sokol +12 more
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Meta‐analysis of clinical metabolic profiling studies in cancer: challenges and opportunities
EMBO Molecular Medicine, 2016 Cancer cell metabolism has received increasing attention. Despite a boost in the application of clinical metabolic profiling (CMP) in cancer patients, a meta‐analysis has not been performed.
Jermaine Goveia +9 more
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