Results 21 to 30 of about 354,639 (240)
VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone
npj Regenerative Medicine, 2023 Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes.
Andrea Grosso +8 more
doaj +1 more source
STAR Protocols, 2021 Summary: Tumor-associated macrophages (TAMs) are highly heterogenous regarding their intratumoral localization, surface marker expression, and molecular properties.
Pawel Bieniasz-Krzywiec +3 more
doaj +1 more source
Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]
, 2016 BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C +12 more
core +1 more source
High mitogenic stimulation arrests angiogenesis
Nature Communications, 2019 High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high ...
Samuel Pontes-Quero +9 more
doaj +1 more source
Publisher Correction: High mitogenic stimulation arrests angiogenesis
Nature Communications, 2019 The original version of this Article contained errors in Fig. 8. In panel a, the labels ‘VEGF’, ‘Notch’, ‘p21’, and ‘P-ERK’ were inadvertently omitted. This has been corrected in the PDF and HTML versions of the Article.
Samuel Pontes-Quero +9 more
doaj +1 more source
How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors
Frontiers in Immunology, 2017 Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life, ECs can rapidly switch to a migratory “tip” cell and a ...
Annalisa Zecchin +7 more
doaj +1 more source
Investigation of the marine compound spongistatin 1 links the inhibition of PKCα translocation to nonmitotic effects of tubulin antagonism in angiogenesis [PDF]
, 2009 The aims of the study were to meet the demand of new tubulin antagonists with fewer side effects by characterizing the antiangiogenic properties of the experimental compound spongistatin 1, and to elucidate nonmitotic mechanisms by which tubulin ...
Bruns, Christiane J. +7 more
core +1 more source
Glycolytic regulation of cell rearrangement in angiogenesis
Nature Communications, 2016 Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing ...
Bert Cruys +15 more
doaj +1 more source
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]
, 2012 The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J. +2 more
core +1 more source