Results 31 to 40 of about 486,070 (267)

Angiogenesis and angiogenesis inhibitors in paediatric diseases

European Journal of Pediatrics, 1992
Angiogenesis, the generation of new capillaries from existing blood vessels, is rarely observed in the healthy organism, but can present during various paediatric diseases. In this review, we describe recent progress in the understanding of pathological angiogenesis and approaches for an improved therapy of angiogenic childhood diseases.
Schweigerer, L., Fotsis, T.
openaire   +3 more sources

A transgenic Xenopus laevis reporter model to study lymphangiogenesis

Biology Open, 2013
Summary The importance of the blood- and lymph vessels in the transport of essential fluids, gases, macromolecules and cells in vertebrates warrants optimal insight into the regulatory mechanisms underlying their development.
Annelii Ny, Wouter Vandevelde, Philipp Hohensinner, Manu Beerens, Ilse Geudens, Antonio Diez-Juan, Katleen Brepoels, Stéphane Plaisance, Paul A. Krieg, Tobias Langenberg, Stefan Vinckier, Aernout Luttun, Peter Carmeliet, Mieke Dewerchin   +13 more
doaj   +1 more source

Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells

Cell Death and Disease, 2021
Dental pulp stem cells (DPSC) are capable of differentiating into vascular endothelial cells. Although the capacity of vascular endothelial growth factor (VEGF) to induce endothelial differentiation of stem cells is well established, mechanisms that ...
Zhaocheng Zhang, Min Oh, Jun-Ichi Sasaki, Jacques E. Nör   +3 more
doaj   +1 more source

Disruption of VEGF Mediated Flk‐1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino‐1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The present study demonstrates that the ubiquitin E3 ligase, Pellino‐1 (Peli1), is an important angiogenic molecule under the control of vascular endothelial growth factor (VEGF) receptor 2/Flk‐1.
Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Mandip Joshi, Vladimir Coca‐Soliz, Leonidas Tapias, IbnalWalid Saad, Craig Fournier, Aaftab Husain, Jacob Campbell, Siu‐Pok Yee, Juan A. Sanchez, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik   +13 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

PHD2 regulates arteriogenic macrophages through TIE2 signalling

EMBO Molecular Medicine, 2013
Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype ...
Alexander Hamm, Lorenzo Veschini, Yukiji Takeda, Sandra Costa, Estelle Delamarre, Mario Leonardo Squadrito, Anne‐Theres Henze, Mathias Wenes, Jens Serneels, Ferdinando Pucci, Carmen Roncal, Andrey Anisimov, Kari Alitalo, Michele De Palma, Massimiliano Mazzone   +14 more
doaj   +1 more source

Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges

Molecular Cancer, 2018
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes.
Ramesh Butti, Sumit Das, Vinoth Prasanna Gunasekaran, Amit Singh Yadav, Dhiraj Kumar, Gopal C. Kundu   +5 more
doaj   +1 more source

Angiogenesis and schistosomiasis [PDF]

Memórias do Instituto Oswaldo Cruz, 2010
Angiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vessels, accompanied by production of vascular-endothelial ...
Andrade, Zilton A., Santana, Thaynã Souto   +1 more
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source