Results 31 to 40 of about 506,292 (219)

The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells

Communications Biology
Endothelial cells (ECs) are highly glycolytic, but whether they generate glycolytic intermediates via gluconeogenesis (GNG) in glucose-deprived conditions remains unknown.
Pauline de Zeeuw, Lucas Treps, Melissa García-Caballero, Ulrike Harjes, Joanna Kalucka, Carla De Legher, Katleen Brepoels, Kristel Peeters, Stefan Vinckier, Joris Souffreau, Ann Bouché, Federico Taverna, Jonas Dehairs, Ali Talebi, Bart Ghesquière, Johan Swinnen, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Peter Carmeliet   +19 more
doaj   +1 more source

Mapping diurnal variations in choroidal sublayer perfusion in patients with idiopathic epiretinal membrane: an optical coherence tomography angiography study

International Journal of Retina and Vitreous, 2019
Background Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the choroidal vasculature and perfusion state. In this index study, OCTA was used to investigate diurnal changes in choroidal sublayer perfusion
Felix Rommel, Fynn Siegfried, Jan A. M. Sochurek, Matthias Rothe, Max P. Brinkmann, Maximilian Kurz, Michelle Prasuhn, Salvatore Grisanti, Mahdy Ranjbar   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway

FEBS Open Bio, 2023
Identifying novel targets that control both tumorigenesis and angiogenesis can aid in developing a more potent anti‐angiogenic therapeutic strategy. We previously reported that reduction of FRG1 is associated with increased p38‐MAPK signaling in prostate
Bratati Mukherjee, Pratush Brahma, Talina Mohapatra, Saurabh Chawla, Manjusha Dixit   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modulation of Immunity by Lymphatic Dysfunction in Lymphedema

Frontiers in Immunology, 2019
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and dysregulated ...
Yinan Yuan, Valeria Arcucci, Sidney M. Levy, Marc G. Achen, Marc G. Achen   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Cross talk Initiated by Endothelial Cells Enhances Migration and Inhibits Anoikis of Squamous Cell Carcinoma Cells through STAT3/Akt/ERK Signaling

Neoplasia: An International Journal for Oncology Research, 2009
It is well known that cancer cells secrete angiogenic factors to recruit and sustain tumor vascular networks. However, little is known about the effect of endothelial cell-secreted factors on the phenotype and behavior of tumor cells.
Kathleen G. Neiva, Zhaocheng Zhang, Marta Miyazawa, Kristy A. Warner, Elisabeta Karl, Jacques E. Nör   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Anti-tumor efficacy and Vδ2 T-cell activation via EGFR antibody-drug conjugates featuring novel aminobisphosphonates

Scientific Reports
Antibody–drug conjugates (ADCs) represent a promising strategy in cancer therapy, enabling the targeted delivery of cytotoxic agents to tumor cells. In this study, we developed and characterized novel ADCs combining the anti-EGFR monoclonal therapeutic ...
Doretta Cuffaro, Linda Di Gregorio, Camilla Mangini, Martina Taglieri, Serena Matis, Roberto Benelli, Massimo Ardy, Laura Salvini, Armando Rossello, Alessandro Poggi, Lizzia Raffaghello, Elisa Nuti   +11 more
doaj   +1 more source