Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis [PDF]
Journal of Vascular Research, 2012 Angiogenesis, i.e. the development and growth of blood vessels, is a major topic of research as it plays an important role in normal development and in various pathologies. Recent evidence revealed the existence of different mechanisms of blood vessel growth, including sprouting and intussusceptive angiogenesis, vascular mimicry, and blood vessel ...
De Spiegelaere, Ward +7 more
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Cold Spring Harbor Perspectives in Biology, 2011 Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult, angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement membrane, and vascular sprouting within interstitial matrix. During this sprouting phase, ECM binding to integrins provides critical signaling support for EC proliferation ...
Donald R, Senger, George E, Davis
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Modelling stromal FAK regulation of tumour growth, angiogenesis and progression [PDF]
, 2012 PhDThe growth of tumours within a whole organism depends on the tumour microenvironment. This involves both resident stromal cells, such as endothelial cells and fibroblasts, and also bone marrow derived stromal cells.
Batista, Silvia
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Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]
, 2013 Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš +17 more
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Angiogenesis "in vitro" of the healthy mouse heart under hypoxia : the role of Angiotensin II and Nitric Oxide [PDF]
, 2005 Angiogenesis is the process by which blood microvessels are formed from existing ones. Angiogenesis is required for development. It is also important for reducing myocardial hypoxia due to coronary and ischemic heart disease; in myocardial infarction ...
Munk, Veronica Cecilia
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New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger +2 more
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The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]
, 2013 Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
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Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling [PDF]
, 2013 The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-
McMahon, Kathryn +25 more
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Publisher Correction: High mitogenic stimulation arrests angiogenesis
Nature Communications, 2019 The original version of this Article contained errors in Fig. 8. In panel a, the labels ‘VEGF’, ‘Notch’, ‘p21’, and ‘P-ERK’ were inadvertently omitted. This has been corrected in the PDF and HTML versions of the Article.
Samuel Pontes-Quero +9 more
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How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors
Frontiers in Immunology, 2017 Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life, ECs can rapidly switch to a migratory “tip” cell and a ...
Annalisa Zecchin +7 more
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