Results 21 to 30 of about 4,056,235 (345)

Impact of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To investigate the effect and underlying mechanism of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells (BMSCs). Methods The osteocytes derived from RosaNotch mice were infected with recombinant
XIE Yingchun, TU Xiaolin
doaj   +1 more source

Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal

Frontiers in Pharmacology, 2023
Background: Aging and oxidative stress are considered to be the proximal culprits of postmenopausal osteoporosis. Eldecalcitol (ED-71), a new active vitamin D derivative, has shown a good therapeutic effect on different types of osteoporosis, but the ...
Yuying Kou, Yuying Kou, Xing Rong, Xing Rong, Rong Tang, Rong Tang, Yuan Zhang, Yuan Zhang, Panpan Yang, Panpan Yang, Hongrui Liu, Hongrui Liu, Wanli Ma, Wanli Ma, Minqi Li, Minqi Li   +15 more
doaj   +1 more source

Nanomaterials and bone regeneration [PDF]

Bone Research, 2015
The worldwide incidence of bone disorders and conditions has been increasing. Bone is a nanomaterials composed of organic (mainly collagen) and inorganic (mainly nano-hydroxyapatite) components, with a hierarchical structure ranging from nanoscale to macroscale.
Gong, Tao, Xie, Jing, Liao, Jinfeng, Zhang, Tao, Lin, Shiyu, Lin, Yunfeng   +5 more
openaire   +2 more sources

The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels [PDF]

European Cells & Materials, 2016
Tissue barriers function as “gate keepers” between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By
C Lehner, R Gehwolf, JC Ek, S Korntner, H Bauer, H-C Bauer, A Traweger, H Tempfer   +7 more
doaj   +1 more source

The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective

Journal of Functional Biomaterials, 2023
The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters,
Markus Laubach, F. Hildebrand, Sinduja Suresh, M. Wagels, Philipp Kobbe, Fabian Gilbert, U. Kneser, B. Holzapfel, D. Hutmacher   +8 more
semanticscholar   +1 more source

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration [PDF]

, 2012
Bone is the second most widely transplanted tissue after blood. Synthetic alternatives are needed that can reduce the need for transplants and regenerate bone by acting as active temporary templates for bone growth.
Lee, P. D., Jones, Julian R., Jones, J. R., J. V. Hanna, Newport, Robert J., Hanna, J. V., Smith, M. E., Smith, Mark E., Smith, M.E., Martin, R.A., Yue, S., Hanna, John V., R. J. Newport, Martin, R. A., Lee, P.D., Jones, J.R., M. E. Smith, J. R. Jones, Newport, R. J., Martin, Richard A., R. A. Martin, P. D. Lee, Hanna, J.V., S. Yue   +23 more
core   +1 more source

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

, 2021
Porous nanomaterials (PNMs) are nanosized materials with specially designed porous structures that have been widely used in the bone tissue engineering field due to the fact of their excellent physical and chemical properties such as high porosity, high ...
Lan Xiao, Xiao, Lan, Xiao, Yin, Yin Xiao, Qing Zhang, Zhang, Qing   +5 more
core   +1 more source

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
doaj   +1 more source

Allergy-induced systemic inflammation impairs tendon quality

EBioMedicine, 2022
Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood.
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Després, Richard Weiss, Herbert Tempfer, Andreas Traweger   +15 more
doaj   +1 more source

Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields

Cells, 2019
Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf, Bettina Schwemberger, Malik Jessen, Stefanie Korntner, Andrea Wagner, Christine Lehner, Nadja Weissenbacher, Herbert Tempfer, Andreas Traweger   +8 more
doaj   +1 more source