Results 1 to 10 of about 80,540 (259)

Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes

Biology, 2021
The Fas ligand (FasL) is known from programmed cell death, the immune system, and recently also from bone homeostasis. As such, Fas signalling is a potential target of anti-osteoporotic treatment based on the induction of osteoclastic cell death.
Adela Kratochvilova, Alice Ramesova, Barbora Vesela, Eva Svandova, Herve Lesot, Reinhard Gruber, Eva Matalova   +6 more
doaj   +1 more source

The patient clinical journey and socioeconomic impact of osteogenesis imperfecta: a systematic scoping review

Orphanet Journal of Rare Diseases, 2023
Background Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder primarily characterised by skeletal deformity and fragility, and an array of secondary features.
Maria Rapoport, Michael B. Bober, Cathleen Raggio, Lena Lande Wekre, Frank Rauch, Ingunn Westerheim, Tracy Hart, Taco van Welzenis, Arun Mistry, James Clancy, Lucy Booth, Samantha Prince, Oliver Semler   +12 more
doaj   +1 more source

Fatigue in adults with Osteogenesis Imperfecta

BMC Musculoskeletal Disorders, 2020
Background Osteogenesis Imperfecta (OI) is characterized by bone fragility, and features such as blue sclerae, dentinogenesis imperfecta, hearing loss, ligamentous laxity and short stature can be present.
Arjan G. J. Harsevoort, Koert Gooijer, Fleur S. van Dijk, Daniëlle A. F. M. van der Grijn, Anton A. M. Franken, Anne Marieke V. Dommisse, Guus J. M. Janus   +6 more
doaj   +1 more source

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor

Frontiers in Cell and Developmental Biology, 2023
As the dentition forms and becomes functional, the alveolar bone is remodelled. Metalloproteinases are known to contribute to this process, but new regulators are emerging and their contextualization is challenging.
S. Varadinkova, S. Varadinkova, V. Oralova, V. Oralova, M. Clarke, J. Frampton, L. Knopfova, L. Knopfova, H. Lesot, P. Bartos, E. Matalova, E. Matalova   +11 more
doaj   +1 more source

“Osteogenesis Imperfecta Patients Wish Orthopedic Surgeons Had Better Strategies to Help with…”—Results of a Patient and Parent-Oriented Survey

Children, 2023
Osteogenesis Imperfecta (OI) is a rare genetic disorder in Type I collagen characterized by bone fractures, fragility, and deformity. Current treatments are focused on decreasing fracture rates, improving bone strength, and improving overall global ...
Jill Flanagan, Laura Tosi, Erika Carter, Tracy Hart, Jeanne Franzone, Maegen Wallace   +5 more
doaj   +1 more source

Formation and Developmental Specification of the Odontogenic and Osteogenic Mesenchymes

Frontiers in Cell and Developmental Biology, 2020
Within the mandible, the odontogenic and osteogenic mesenchymes develop in a close proximity and form at about the same time. They both originate from the cranial neural crest. These two condensing ecto-mesenchymes are soon separated from each other by a
Eva Svandova, Renata Peterkova, Eva Matalova, Eva Matalova, Herve Lesot   +4 more
doaj   +1 more source

Caspase-12 Is Present During Craniofacial Development and Participates in Regulation of Osteogenic Markers

Frontiers in Cell and Developmental Biology, 2020
Caspases are evolutionary conserved proteases traditionally known as participating in apoptosis and inflammation but recently discovered also in association with other processes such as proliferation or differentiation.
Barbora Vesela, Adela Kratochvilova, Eva Svandova, Petr Benes, Kamila Rihova, Anne Poliard, Eva Matalova, Eva Matalova   +7 more
doaj   +1 more source

The application of biomaterials in osteogenesis: A bibliometric and visualized analysis

Frontiers in Bioengineering and Biotechnology, 2022
Osteogenesis serves an important role in bone tissue repairing. Novel biomaterials are widely prevalent as materials for orthopedic implants due to their biocompatibility and osteogenetic ability.
Jie Wang, Yuan Chi, Yuan Chi, Baohui Yang, Qiongchi Zhang, Dong Wang, Xijing He, Haopeng Li   +7 more
doaj   +1 more source

Adults with osteogenesis imperfecta: Clinical characteristics of 151 patients with a focus on bisphosphonate use and bone density measurements

Bone Reports, 2018
An expert center for adults with Osteogenesis Imperfecta (OI) has been founded at the Isala Hospital in Zwolle, the Netherlands to achieve optimal care for adults with OI.
Luuk J.J. Scheres, Fleur S. van Dijk, Arjan J. Harsevoort, Atty T.H. van Dijk, Anne Marieke Dommisse, Guus J.M. Janus, Anton A.M. Franken   +6 more
doaj   +1 more source

A roadmap to surgery in osteogenesis imperfecta: results of an international collaboration of patient organizations and interdisciplinary care teams

Acta Orthopaedica, 2021
Background and purpose — Involvement of patient organizations is steadily increasing in guidelines for treatment of various diseases and conditions for better care from the patient’s viewpoint and better comparability of outcomes.
Ralph J Sakkers, Kathleen Montpetit, Argerie Tsimicalis, Thomas Wirth, Marjolein Verhoef, Reginald Hamdy, Jean A Ouellet, Rene M Castelein, Chantal Damas, Guus J Janus, Wouter H Nijhuis, Leonardo Panzeri, Simona Paveri, Dagmar Mekking, Kelly Thorstad, Richard W Kruse   +15 more
doaj   +1 more source