Results 21 to 30 of about 165,191 (338)

Impact of FasL Stimulation on Sclerostin Expression and Osteogenic Profile in IDG-SW3 Osteocytes

Biology, 2021
The Fas ligand (FasL) is known from programmed cell death, the immune system, and recently also from bone homeostasis. As such, Fas signalling is a potential target of anti-osteoporotic treatment based on the induction of osteoclastic cell death.
Adela Kratochvilova, Alice Ramesova, Barbora Vesela, Eva Svandova, Herve Lesot, Reinhard Gruber, Eva Matalova   +6 more
doaj   +1 more source

The patient clinical journey and socioeconomic impact of osteogenesis imperfecta: a systematic scoping review

Orphanet Journal of Rare Diseases, 2023
Background Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder primarily characterised by skeletal deformity and fragility, and an array of secondary features.
Maria Rapoport, Michael B. Bober, Cathleen Raggio, Lena Lande Wekre, Frank Rauch, Ingunn Westerheim, Tracy Hart, Taco van Welzenis, Arun Mistry, James Clancy, Lucy Booth, Samantha Prince, Oliver Semler   +12 more
doaj   +1 more source

Regulation of Osteoimmune Microenvironment and Osteogenesis by 3D‐Printed PLAG/black Phosphorus Scaffolds for Bone Regeneration

Advancement of science, 2023
The treatment of bone defects remains a significant challenge to be solved clinically. Immunomodulatory properties of orthopedic biomaterials have significance in regulating osteoimmune microenvironment for osteogenesis.
J. Long, Zhen-Yu Yao, Wei Zhang, Ben Liu, Kai-Ming Chen, Long Li, Bin Teng, Xiangfu Du, Cai-Rong Li, Xue-Feng Yu, Ling Qin, Y. Lai   +11 more
semanticscholar   +1 more source

Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Journal of Nanobiotechnology, 2023
Despite the recent advances in the development of bone graft substitutes, treatment of critical size bone defects continues to be a significant challenge, especially in the elderly population.
Arezoo Saberi, Maryam Kouhjani, Marzieh Mohammadi, Leticia Hosta-Rigau   +3 more
semanticscholar   +1 more source

Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair

Genes and Diseases, 2023
Bone defects caused by diseases or surgery are a common clinical problem. Researchers are devoted to finding biological mechanisms that accelerate bone defect repair, which is a complex and continuous process controlled by many factors.
Hao Wang, Hui Yu, Tianyu Huang, Bin Wang, Lin-Ling Xiang   +4 more
semanticscholar   +1 more source

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

Nature, 2021
Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic stem cells and early restricted progenitors1–6.
Bo Shen, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Jingzhu Zhang, E. Nosyreva, Li-Ming Du, Malea M. Murphy, Shui-Qing Hu, Y. Yi, Nergis Kara, Xin Liu, Shay Guela, Yue-Meng Jia, V. Ramesh, Claire Embree, Evann C Mitchell, Y. Zhao, L. Ju, Zhao Hu, G. Crane, Zhi-Yu Zhao, Ruhma Syeda, S. Morrison   +22 more
semanticscholar   +1 more source

Osteogenesis Imperfecta: An Overview [PDF]

, 2022
Osteogenesis Imperfecta (OI) or commonly referred to as brittle bone disease is a congenital connective tissue formation disorder characterized by bone fragility, osteopenia, skin disorders, blue sclera, dentinogenesis imperfecta (DI), and hearing loss ...
Rahma Ira Mustikasari, -, Nur Rochmah, -, Muhammad Faizi, -, Qurrota Ayuni Novia Putri, -   +3 more
core   +4 more sources

Fatigue in adults with Osteogenesis Imperfecta

BMC Musculoskeletal Disorders, 2020
Background Osteogenesis Imperfecta (OI) is characterized by bone fragility, and features such as blue sclerae, dentinogenesis imperfecta, hearing loss, ligamentous laxity and short stature can be present.
Arjan G. J. Harsevoort, Koert Gooijer, Fleur S. van Dijk, Daniëlle A. F. M. van der Grijn, Anton A. M. Franken, Anne Marieke V. Dommisse, Guus J. M. Janus   +6 more
doaj   +1 more source

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor

Frontiers in Cell and Developmental Biology, 2023
As the dentition forms and becomes functional, the alveolar bone is remodelled. Metalloproteinases are known to contribute to this process, but new regulators are emerging and their contextualization is challenging.
S. Varadinkova, S. Varadinkova, V. Oralova, V. Oralova, M. Clarke, J. Frampton, L. Knopfova, L. Knopfova, H. Lesot, P. Bartos, E. Matalova, E. Matalova   +11 more
doaj   +1 more source

“Osteogenesis Imperfecta Patients Wish Orthopedic Surgeons Had Better Strategies to Help with…”—Results of a Patient and Parent-Oriented Survey

Children, 2023
Osteogenesis Imperfecta (OI) is a rare genetic disorder in Type I collagen characterized by bone fractures, fragility, and deformity. Current treatments are focused on decreasing fracture rates, improving bone strength, and improving overall global ...
Jill Flanagan, Laura Tosi, Erika Carter, Tracy Hart, Jeanne Franzone, Maegen Wallace   +5 more
doaj   +1 more source